Gemcitabine hydrochloride
- CAS No.
- 122111-03-9
- Chemical Name:
- Gemcitabine hydrochloride
- Synonyms
- GEMCITABINE HCL;gemzar;Gecitabine;4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1h-pyrimidin-2-one hydrochloride;DFDC;DDFC;DFDCYD;GeMsar;T11YSY;ly188011
- CBNumber:
- CB7232767
- Molecular Formula:
- C9H12ClF2N3O4
- Molecular Weight:
- 299.66
- MOL File:
- 122111-03-9.mol
- Modify Date:
- 2024/4/15 18:41:30
| Melting point | >250°C dec. |
|---|---|
| alpha | D +48°; 365 +257.9° (c = 1.0 in deuterated water) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥10mg/mL |
| form | White powder |
| color | White |
| λmax | 268nm(H2O)(lit.) |
| Merck | 14,4386 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 122111-03-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 21-36/38-46-62-63 | |||||||||
| Safety Statements | 25-26-36/37-53 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HA3840000 | |||||||||
| HS Code | 29420000 | |||||||||
| NFPA 704 |
|
Gemcitabine hydrochloride price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2582 | Gemcitabine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 50?mg | 122111-03-9 | 50MG | ₹11279.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G6423 | Gemcitabine hydrochloride ≥98% (HPLC) | 122111-03-9 | 10MG | ₹8746.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G6423 | Gemcitabine hydrochloride ≥98% (HPLC) | 122111-03-9 | 50MG | ₹34943.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.04594 | Gemcitabine, HCl - CAS 122111-03-9 - Calbiochem | 122111-03-9 | 50MG | ₹17660.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0367 | Gemcitabine Hydrochloride | 122111-03-9 | 100MG | ₹9700 | 2022-05-26 | Buy |
Gemcitabine hydrochloride Chemical Properties,Uses,Production
Description
Gemcitabine is a novel nucleoside analog that was launched in 1995 in the Netherlands for the treatment of non-small cell lung cancer (nsclc) and in Sweden for pancreatic cancer. Gemcitabine is a prodrug which is phosphorylated intracellularly by deoxycytadine kinase to its active forms, the di- and triphosphates which bind to DNA competitively. This insertion inhibits processes required for DNA synthesis and metabolism, the essential function for both cell replication and repair. Furthermore, gemcitabine displays an extraordinary array of self-potentiating mechanisms that increase the concentration and prolong the retention of its active nucleotides in tumor cells. The title compound has shown activity against a wide spectrum of human solid tumors including colon, mammary, breast, bladder cancers. Synergistic activity of gemcitabine with other anticancer agents such as cisplatin has been reported.
Chemical Properties
White crystalline granular, odorless
Definition
ChEBI: A 2'-deoxycytidine hydrochloriode having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine hydrochloride is used in the treatment of various carcinomas, including non-small cell lung cancer, pancreatic ca cer, bladder cancer and breast cancer.
Biological Activity
Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo .
Gemcitabine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 337 | 58 | Inquiry |
| Meenaakshi Molecules Pvt Ltd | +91-9121311126 +91-9121311126 | Telangana, India | 45 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Vannsh Life Sciences Pvt Ltd | +91-4023555246 +91-9642555246 | Hyderabad, India | 15 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
122111-03-9(Gemcitabine hydrochloride)Related Search:
1of4
chevron_right