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Metacycline hydrochloride

Metacycline hydrochloride Structure
CAS No.
3963-95-9
Chemical Name:
Metacycline hydrochloride
Synonyms
METACYCLINE;METHACYCLINE HYDROCHLORIDE;METHACYCLINE HCL;METACYCLINE HCL;optimycin;metadomus;MethacycL;londomycin;megamycine;adriamicina
CBNumber:
CB2355197
Molecular Formula:
C22H23ClN2O8
Molecular Weight:
478.88
MOL File:
3963-95-9.mol
MSDS File:
SDS
Modify Date:
2024/12/18 14:07:02
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Metacycline hydrochloride Properties

Melting point >224°C(dec.)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
form Crystalline Powder
color Yellow
BRN 5470951
CAS DataBase Reference 3963-95-9
EPA Substance Registry System Methacycline hydrochloride (3963-95-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H335-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety Statements  24/25-22
WGK Germany  2
RTECS  QI9276000
HS Code  29413020
Toxicity LD50 in rats, mice (mg/kg): 252, 288 i.p. (Goldenthal)
NFPA 704
0
2 0

Metacycline hydrochloride price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1594 Methacycline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 3963-95-9 1G ₹15966.88 2022-06-14 Buy
Product number Packaging Price Buy
PHR1594 1G ₹15966.88 Buy

Metacycline hydrochloride Chemical Properties,Uses,Production

Description

Methacycline is a tetracycline-class antibiotic that is active against a wide range of Gram-positive and Gram-negative organisms. It is readily absorbed from the gastrointestinal tract and reaches a maximum concentration at about the fourth hour, declining to a negligible amount in about 24 hours. It is more active than tetracycline against a number of bacteria.

Chemical Properties

yellow crystalline powder

Uses

Broad spectrum, semisynthetic antibiotic related to Tetracycline. Antibacterial.

General Description

The synthesis of methacycline, 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride (Rondomycin), reportedby Blackwood et al. in 1961, was accomplished bychemical modification of oxytetracycline. It has an antibioticspectrum like that of the other tetracyclines but greater potency;about 600 mg of methacycline is equivalent to 1 g oftetracycline. Its particular value lies in its longer serum halflife;doses of 300 mg produce continuous serum antibacterialactivity for 12 hours. Its toxic manifestations and contraindicationsare similar to those of the other tetracyclines.
The greater stability of methacycline, both in vivo and invitro, results from modification at C-6. Removal of the 6-hydroxy group markedly increases the stability of ring C toboth acids and bases, preventing the formation of isotetracyclinesby bases. Anhydrotetracyclines still can form, however,by acid-catalyzed isomerization under strongly acidicconditions. Methacycline hydrochloride is a yellow to darkyellow, crystalline powder that is slightly soluble in waterand insoluble in nonpolar solvents. It should be stored intight, light-resistant containers in a cool place.

Metacycline hydrochloride Preparation Products And Raw materials

Raw materials

Oxytetracycline Sulfur trioxide Hydrogen fluoride

Preparation Products

Metacycline hydrochloride Suppliers

Global( 281)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Chemicea Pharmaceuticals Pvt Ltd +91-918482849343 +91-8482849343 Mumbai, India 461 58 Inquiry
Molsyns Research +91-9586858886 +91-9586858886 Gujarat, India 418 58 Inquiry
Allmpus Laboratories Pvt Ltd +91-9518738415 +91-9167862134 Maharashtra, India 657 58 Inquiry
Manus Aktteva Biopharma LLP 08048250218Ext 800 Ahmedabad, India 655 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6514 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3887 58 Inquiry
Supplier Advantage
Chemicea Pharmaceuticals Pvt Ltd 58
Molsyns Research 58
Allmpus Laboratories Pvt Ltd 58
Manus Aktteva Biopharma LLP 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Clearsynth Labs 58

Metacycline hydrochloride Spectrum

Metacycline hydrochloride(3963-95-9)1HNMR

3963-95-9(Metacycline hydrochloride )Related Search:

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Methacycline Hydrochloride (200 mg)I0C348903ug/mg(ai) Methacycline HCl (PhysioMycine) Rondomycin hydrochloride 6-Methyleneoxytetracycline hydrochloride, Metacycline hydrochloride, LondoMycin (4S,4aR,5S,5aR,12aS)- 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide, hydrochloride (1:1) Methacycline hydrochloride Solution, 100ppm Hydrochloric acid methacycline 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLINE MONOHYDROCHLORIDE 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLNE HYDROCHLORIDE METACYCLINE HYDROCHLORIDE 12,12a-pentahydroxy-6-methylene-1,11-dioxo-1monohydrochloride metilenbiotic optimycin physiomycine Metacycline hydrochloride, sec. Standard, 98% 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,12aS)- METHACYCLINE HYDROCHLORIDE (METACYCLINE HYDROCHLORIDE) METACYCLINE HYDROCHLORIDE, 98%, SEC. STANDARD Metacylcline HLC (4S,4aR,5S,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-Methylene-1,11-dioxo-2-naphthacenecarboxaMide HCl Methacycline hydrochloride (PhysioMycine) adriamicina ciclobiotic germiciclin globociclina londomycin megamycine metadomus methacyclinemonohydrochloride Metacyclin hydrochloride Methacycline Hydrochloride (200 mg) Metacycline hydrochloride USP/EP/BP (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride Methacycline HydrochlorideQ: What is Methacycline Hydrochloride Q: What is the CAS Number of Methacycline Hydrochloride Q: What is the storage condition of Methacycline Hydrochloride Q: What are the applications of Methacycline Hydrochloride Metacyclinhydrochlorid Methacycline Hydrochloride (1397006) MethacycL Methacycline hydrochlorid 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride Metacycline, Adramycin, Rondomycin, Pindex Methacycline hydrochloride, potency: 877 u/mg METACYCLINE METACYCLINE HCL METHACYCLINE HCL METHACYCLINE HYDROCHLORIDE Doxycycline EP Impurity B / Methacycline Impurity (4S,4Ar,5S,5aR,12aS)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Doxycycline Hyclate EP Impurity B as Hydrochloride Doxycycline EP Impurity B（HCl） Methicycline hydrochloride Methacylcycline Hydrochloride C14917000 MetacyclinEhydrochloride Methacycline hydrochloride 100 μg/ml Acetonitrile Methacycline hydrochloride, 10 mM in DMSO 3963-95-9 C22H22N2O8ClH Amines Chiral Reagents