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Metacycline hydrochloride

CAS No.: 3963-95-9

Chemical Name:: Metacycline hydrochloride

Synonyms: METACYCLINE;METHACYCLINE HYDROCHLORIDE;METHACYCLINE HCL;METACYCLINE HCL;optimycin;metadomus;MethacycL;londomycin;megamycine;adriamicina

CBNumber:: CB2355197

Molecular Formula:: C22H23ClN2O8

Molecular Weight:: 478.88

MOL File:: 3963-95-9.mol

MSDS File:: SDS

Modify Date:: 2023/6/8 9:02:50

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Metacycline hydrochloride Properties

Melting point	>224°C(dec.)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
form	Crystalline Powder
color	Yellow
BRN	5470951
CAS DataBase Reference	3963-95-9
EPA Substance Registry System	Methacycline hydrochloride (3963-95-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335-H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Safety Statements

24/25-22

WGK Germany

RTECS

QI9276000

HS Code

29413020

Toxicity

LD50 in rats, mice (mg/kg): 252, 288 i.p. (Goldenthal)

NFPA 704

	0
2		0

Metacycline hydrochloride price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR1594	Methacycline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material	3963-95-9	1G	₹15966.88	2022-06-14	Buy

Product number	Packaging	Price	Buy
PHR1594	1G	₹15966.88	Buy

Metacycline hydrochloride Chemical Properties,Uses,Production

Description

Methacycline is a tetracycline-class antibiotic that is active against a wide range of Gram-positive and Gram-negative organisms. It is readily absorbed from the gastrointestinal tract and reaches a maximum concentration at about the fourth hour, declining to a negligible amount in about 24 hours. It is more active than tetracycline against a number of bacteria.

Chemical Properties

yellow crystalline powder

Uses

Broad spectrum, semisynthetic antibiotic related to Tetracycline. Antibacterial.

General Description

The synthesis of methacycline, 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride (Rondomycin), reportedby Blackwood et al. in 1961, was accomplished bychemical modification of oxytetracycline. It has an antibioticspectrum like that of the other tetracyclines but greater potency;about 600 mg of methacycline is equivalent to 1 g oftetracycline. Its particular value lies in its longer serum halflife;doses of 300 mg produce continuous serum antibacterialactivity for 12 hours. Its toxic manifestations and contraindicationsare similar to those of the other tetracyclines.
The greater stability of methacycline, both in vivo and invitro, results from modification at C-6. Removal of the 6-hydroxy group markedly increases the stability of ring C toboth acids and bases, preventing the formation of isotetracyclinesby bases. Anhydrotetracyclines still can form, however,by acid-catalyzed isomerization under strongly acidicconditions. Methacycline hydrochloride is a yellow to darkyellow, crystalline powder that is slightly soluble in waterand insoluble in nonpolar solvents. It should be stored intight, light-resistant containers in a cool place.

Metacycline hydrochloride Preparation Products And Raw materials

Raw materials

Oxytetracycline Sulfur trioxide Hydrogen fluoride

Preparation Products

Metacycline hydrochloride Suppliers

Global( 259)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Chemicea Pharmaceuticals Pvt Ltd	+91-918482849343 +91-8482849343	Mumbai, India	461	58	Inquiry
Molsyns Research	+91-9586858886 +91-9586858886	Gujarat, India	418	58	Inquiry
Manus Aktteva Biopharma LLP	08048250218Ext 800	Ahmedabad, India	655	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry

Supplier	Advantage
Chemicea Pharmaceuticals Pvt Ltd	58
Molsyns Research	58
Manus Aktteva Biopharma LLP	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Clearsynth Labs	58
Henan Tianfu Chemical Co.,Ltd.	55

Metacycline hydrochloride Spectrum

Metacycline hydrochloride(3963-95-9)¹HNMR

3963-95-9(Metacycline hydrochloride )Related Search:

Phenylhydrazine hydrochloride Ceftiofur sodium Lincomycin hydrochloride Josamycin Moxifloxacin hydrochloride

Mestinon Tariquidar Trifluridine Formestane Floxuridine

Norvoncomycin hydrochloride BETAZOLE HYDROCHLORIDE Xylazine Hydrochloride SPECTINOMYCIN DIHYDROCHLORIDE Hydralazine hydrochloride

Oxytetracycline METHACYCLINE HCL,METHACYCLINE HYDROCHLORIDE,Methacycline Hydrochloride BP73/USP25 1-ACETYL-1-CYCLOHEXENE

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Methacycline Hydrochloride (200 mg)I0C348903ug/mg(ai) Methacycline HCl (PhysioMycine) Rondomycin hydrochloride 6-Methyleneoxytetracycline hydrochloride, Metacycline hydrochloride, LondoMycin (4S,4aR,5S,5aR,12aS)- 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide, hydrochloride (1:1) Methacycline hydrochloride Solution, 100ppm Hydrochloric acid methacycline 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLINE MONOHYDROCHLORIDE 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLNE HYDROCHLORIDE METACYCLINE HYDROCHLORIDE 12,12a-pentahydroxy-6-methylene-1,11-dioxo-1monohydrochloride metilenbiotic optimycin physiomycine Metacycline hydrochloride, sec. Standard, 98% 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,12aS)- METHACYCLINE HYDROCHLORIDE (METACYCLINE HYDROCHLORIDE) METACYCLINE HYDROCHLORIDE, 98%, SEC. STANDARD Metacylcline HLC (4S,4aR,5S,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-Methylene-1,11-dioxo-2-naphthacenecarboxaMide HCl Methacycline hydrochloride (PhysioMycine) adriamicina ciclobiotic germiciclin globociclina londomycin megamycine metadomus methacyclinemonohydrochloride Metacyclin hydrochloride Methacycline Hydrochloride (200 mg) Metacycline hydrochloride USP/EP/BP (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride Methacycline HydrochlorideQ: What is Methacycline Hydrochloride Q: What is the CAS Number of Methacycline Hydrochloride Q: What is the storage condition of Methacycline Hydrochloride Q: What are the applications of Methacycline Hydrochloride Metacyclinhydrochlorid Methacycline Hydrochloride (1397006) MethacycL Methacycline hydrochlorid 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride Metacycline, Adramycin, Rondomycin, Pindex Methacycline hydrochloride, potency: 877 u/mg METACYCLINE METACYCLINE HCL METHACYCLINE HCL METHACYCLINE HYDROCHLORIDE Doxycycline EP Impurity B / Methacycline Impurity (4S,4Ar,5S,5aR,12aS)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Doxycycline Hyclate EP Impurity B as Hydrochloride Doxycycline EP Impurity B（HCl） Methicycline hydrochloride Methacylcycline Hydrochloride 3963-95-9 C22H22N2O8ClH Amines Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals NUBAIN