Hydralazine hydrochloride
![Hydralazine hydrochloride Structure](CAS/GIF/304-20-1.gif)
- CAS No.
- 304-20-1
- Chemical Name:
- Hydralazine hydrochloride
- Synonyms
- Apulon;Lopres;Asozart;Hyperex;Lopress;apresine;Dralzine;HSDB 434;Rolazine;Hyperazin
- CBNumber:
- CB5113442
- Molecular Formula:
- C8H9ClN4
- Molecular Weight:
- 196.64
- MOL File:
- 304-20-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
Melting point | 273°C |
---|---|
Boiling point | 322.13°C (rough estimate) |
Density | 1.2961 (rough estimate) |
refractive index | 1.6110 (estimate) |
storage temp. | 2-8°C |
solubility | Soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride |
form | Solid |
color | White to Almost white |
PH | pH (20g/l, 25℃) : 3.5~4.5 |
Water Solubility | Soluble in water. Slightly soluble in diethyl ether and alcohol. |
Merck | 14,4763 |
BRN | 3568329 |
BCS Class | 3 |
Stability | Stable. Incompatible with strong oxidizing agents. |
InChIKey | ZUXNZUWOTSUBMN-UHFFFAOYSA-N |
CAS DataBase Reference | 304-20-1(CAS DataBase Reference) |
EPA Substance Registry System | 1(2H)-Phthalazinone, hydrazone, monohydrochloride (304-20-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H315-H319-H335 | |||||||||
Precautionary statements | P301+P330+P331+P310-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26-36/37/39-45 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TH9000000 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29339900 | |||||||||
Toxicity | LD50 oral in rat: 280mg/kg | |||||||||
NFPA 704 |
|
Hydralazine hydrochloride price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | H1753 | Hydralazine hydrochloride | 304-20-1 | 5G | ₹4189.28 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H1753 | Hydralazine hydrochloride | 304-20-1 | 10G | ₹10500.25 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR3184 | Hydralazine Hydrochloride pharmaceutical secondary standard, certified reference material | 304-20-1 | 500MG | ₹18380.85 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H1753 | Hydralazine hydrochloride | 304-20-1 | 50G | ₹36177.15 | 2022-06-14 | Buy |
TCI Chemicals (India) | H0409 | 1-Hydrazinophthalazine Hydrochloride | 304-20-1 | 5G | ₹3300 | 2022-05-26 | Buy |
Hydralazine hydrochloride Chemical Properties,Uses,Production
Description
Hydralazine is an orally bioavailable vasodilator and antihypertensive agent. It decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate (PMA; ) at a concentration of 100 μM. Hydralazine (100 μM) also decreases nitric oxide production and mRNA expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS (Item Nos. 19660| 19661| 19662) and interferon-γ (IFN-γ). It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (; IC50s = 2.2 and 3.06 mM, respectively). Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats. Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.
Chemical Properties
White Crystalline Solid
Uses
Hydralazine hydrochloride has been used:
- as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats
- as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury
- as a vasodilator to study its effects on insulin secretion and glucose tolerance
Definition
ChEBI: The hydrochloride salt of hydralazine; a direct-acting vasodilator that is used as an antihypertensive agent.
General Description
Hydralazine hydrochloride,1-hydrazinophthalazine monohydrochloride(Apresoline hydrochloride), originated from the work of achemist attempting to produce some unusual chemicalcompounds and from the observation that this compoundhad antihypertensive properties. It occurs as yellow crystalsand is soluble in water to the extent of about 3%. A 2%aqueous solution has a pH of 3.5 to 4.5.
Contact allergens
Hydralazine is a hydrazine derivative used as a antihypertensive drug. Skin rashes have been described during treatment. Exposure occurs mainly in the pharmaceutical industry. Cross-sensitivity is frequent with hydrazine, which is considered to be a potent sensitizer.
Mechanism of action
The only drug in this group, hydralazine, does not fit neatly into the other mechanistic classes, in part because its mechanism of action is not entirely clear. It appears to have multiple, direct effects on the VSM. Hydralazine, a phthalazine-substituted hydrazine antihypertensive drug with a pKa of 7.3, is highly specific for arterial vessels, producing its vasodilation by a couple of different mechanisms. First, it causes smooth muscle hyperpolarization, quite likely through the opening of K+ channels. Activation therefore increases the efflux of potassium ions from the cells, causing hyperpolarization of VSM cells and, thus, prolonging the opening of the potassium channel and sustaining a greater vasodilation on arterioles than on veins. It also may inhibit the second messenger, IP3-induced release of calcium from the smooth muscle sarcoplasmic reticulum (the PIP2 signal transduction pathway). Finally, hydralazine stimulates the formation of NO by the vascular endothelium, leading to cGMP-mediated vasodilation. The arterial vasodilator action of hydralazine reduces systemic vascular resistance and arterial pressure. Diastolic blood pressure usually is decreased more than systolic pressure is. The hydralazine-induced decrease in blood pressure and peripheral resistance causes a reflex response, which is accompanied by increased heart rate, cardiac output, stroke volume, and an increase in plasma renin activity. It has no direct effect on the heart. This reflex response could offset the hypotensive effect of arteriolar dilation, limiting its antihypertensive effectiveness. Hydralazine also causes sodium and water retention and expansion of plasma volume, which could develop tolerance to its antihypertensive effect during prolonged therapy. Thus, coadministration of a diuretic improves the therapeutic outcome.
Clinical Use
Hydralazine hydrochloride is useful in the treatment ofmoderate-to-severe hypertension. It is often used in conjunctionwith less potent antihypertensive agents, becauseside effects occur frequently when it is used alone in adequatedoses. In combinations, it can be used in lower andsafer doses. Its action appears to be centered on the smoothmuscle of the vascular walls, with a decrease in peripheralresistance to blood flow. This results in increased bloodflow through the peripheral blood vessels. It also has theunique property of increasing renal blood flow, an importantconsideration in patients with renal insufficiency.Hydralazine hydrochloride acts on vascular smooth muscleto cause relaxation. Its mechanism of action is unclear. Itinterferes with Ca2+ entry andCa2+release from intracellularstores and reportedly causes activation of guanylate cyclase,resulting in increased levels of cGMP. All of thesebiochemical events can cause vasodilation.
Drug interactions
The coadministration of diuretics and other hypotensive drugs may have a synergistic effect, resulting in a marked decrease in blood pressure.
Purification Methods
It crystallises from MeOH and has m 172-173o(dec). [Druey et al. Helv Chim Acta 34 195 1951, Beilstein 25 III/IV 4552.] It is an antihypertensive.
Hydralazine hydrochloride Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
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Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
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GLENMARK LIFE SCIENCES LTD | +91 22 4018 9999 | New Delhi, India | 103 | 58 | Inquiry |
Srimatha Pharmaceuticals. | 91--9618932157 | Hyderabad, India | 26 | 58 | Inquiry |
Jai Radhe Sales | 0091-79-26431096 | New Delhi, India | 157 | 57 | Inquiry |