Ambroxol hydrochloride
- CAS No.
- 23828-92-4
- Chemical Name:
- Ambroxol hydrochloride
- Synonyms
- AMBROXOL HCL;Antobron;MUCOSOLVAN;Ambroxol HCI;Ambroxol Hydrochlorid;AMBRIL;Ambron;Ankisol;FLUIXOL;ABRAMEN
- CBNumber:
- CB4304139
- Molecular Formula:
- C13H19Br2ClN2O
- Molecular Weight:
- 414.56
- MOL File:
- 23828-92-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:08
| Melting point | 233-234.5°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride. |
| form | Solid |
| color | White to Off-White |
| PH | pH(10g/l, 25℃) : 4.0～6.0 |
| Water Solubility | Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml). |
| Merck | 14,386 |
| InChI | InChI=1/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-; |
| InChIKey | QNVKOSLOVOTXKF-PFWPSKEQSA-N |
| SMILES | [C@@H]1(O)CC[C@@H](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl |&1:0,4,r| |
| CAS DataBase Reference | 23828-92-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GV8423000 | |||||||||
| HS Code | 29221980 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn) | |||||||||
| NFPA 704 |
|
Ambroxol hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2063 | Ambroxol Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 23828-92-4 | 300MG | ₹11626.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9797 | Ambroxol hydrochloride analytical standard | 23828-92-4 | 5G | ₹13282.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2360 | Ambroxol Hydrochloride | 23828-92-4 | 5G | ₹10000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2360 | Ambroxol Hydrochloride | 23828-92-4 | 25G | ₹16300 | 2022-05-26 | Buy |
Ambroxol hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Powder
Definition
ChEBI: Ambroxol hydrochloride is an aromatic amine. it is a metabolite of bromhexine that stimulates mucociliary action and clears the air passages in the respiratory tract. it is usually administered as the hydrochloride.
Indications
Ambroxol Hydrochloride is a bronchosecretolytic drug. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.
Biological Activity
Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC 50 values for tonic block are 35.2 and 111.5 μ M respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Mode of action
Ambroxol is the active metabolite of bromhexine. Ambroxol causes an increase in secretion in the respiratory tract. It promotes surfactant production and stimulates ciliary activity. These effects assist the flow of mucus and its removal (mucociliary clearance). An improvement in mucociliary clearance was demonstrated in clinical pharmacological studies. The increase in secretion and mucociliary clearance facilitate expectoration and reduce the cough. In in vitro studies ambroxol showed a significant reduction in cytokine release, both in the blood and in mononuclear and polynuclear cells. The clinical relevance of these findings is unclear.
Ambroxol hydrochloride Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| SUPREME DRUGS PVT LTD | +91-9924961799 +91-9924961799 | Hyderabad, India | 34 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| Devendra Kirti Pharmachem Pvt Ltd | +91-9326475110 +91-9326475110 | Maharashtra, India | 7 | 58 | Inquiry |
| Anuh Pharma Ltd (SK GROUP) | +912266227575 | Maharashtra, India | 38 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| HEMA PHARMACEUTICALS PVT LTD | 58 |
| THE MOLECULEZ | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Frolic Pharmachem | 58 |
| SUPREME DRUGS PVT LTD | 58 |
| Chynops Pharma | 58 |
| Anant Pharmaceuticals Pvt Ltd | 58 |
| Devendra Kirti Pharmachem Pvt Ltd | 58 |
| Anuh Pharma Ltd (SK GROUP) | 58 |