Hydralazine hydrochloride
Hydralazine hydrochloride
- CAS:
- 304-20-1
- MF:
- C8H9ClN4
- MW:
- 196.64
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Company Type
Properties
- Melting point:
- 273°C
- Boiling point:
- 322.13°C (rough estimate)
- Density
- 1.2961 (rough estimate)
- refractive index
- 1.6110 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride
- form
- Solid
- color
- White to Almost white
- PH
- pH (20g/l, 25℃) : 3.5～4.5
- Water Solubility
- Soluble in water. Slightly soluble in diethyl ether and alcohol.
- Merck
- 14,4763
- BRN
- 3568329
- BCS Class
- 3
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- ZUXNZUWOTSUBMN-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301-H315-H319-H335
- Precautionary statements
- P301+P330+P331+P310-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- TH9000000
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29339900
- Toxicity
- LD50 oral in rat: 280mg/kg
Use
Hydralazine hydrochloride is useful in the treatment ofmoderate-to-severe hypertension. It is often used in conjunctionwith less potent antihypertensive agents, becauseside effects occur frequently when it is used alone in adequatedoses. In combinations, it can be used in lower andsafer doses. Its action appears to be centered on the smoothmuscle of the vascular walls, with a decrease in peripheralresistance to blood flow. This results in increased bloodflow through the peripheral blood vessels. It also has theunique property of increasing renal blood flow, an importantconsideration in patients with renal insufficiency.Hydralazine hydrochloride acts on vascular smooth muscleto cause relaxation. Its mechanism of action is unclear. Itinterferes with Ca2+ entry andCa2+release from intracellularstores and reportedly causes activation of guanylate cyclase,resulting in increased levels of cGMP. All of thesebiochemical events can cause vasodilation.
49 India supplier list of "Hydralazine hydrochloride"
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Hydralazine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Hydralazinehydrochloride
- Products Intro:Brand:sigma aldrich | Product Number:H1753
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Hydralazine HCl 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.160342
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Hydralazine hydrochloride
- Company Type: Trader
- Country/Region: New Delhi,INDIA