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Josamycin

Josamycin Structure
CAS No.
16846-24-5
Chemical Name:
Josamycin
Synonyms
C12662;EN 141;Jomybel;YL-704A3;Iosalide;Josacine;Josamina;Wilprafen;Vilprafen;JOSAMYCIN
CBNumber:
CB5444692
Molecular Formula:
C42H69NO15
Molecular Weight:
827.99
MOL File:
16846-24-5.mol
MSDS File:
SDS
Modify Date:
2024/4/10 11:19:08
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Josamycin Properties

Melting point 131.5℃
alpha D25 -70° (c = 1 in ethanol)
Boiling point 763.27°C (rough estimate)
Density 1.1547 (rough estimate)
refractive index 1.6220 (estimate)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in ethanol
pka 7.1 (40% aq methanol)
form powder
color white to slightly yellow
Merck 13,5286
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  2
RTECS  OH4725810
F  10
Toxicity LD50 oral in rat: > 7gm/kg

Josamycin price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 59983 Josamycin ≥90% (HPLC) 16846-24-5 50MG ₹5282.6 2022-06-14 Buy
Product number Packaging Price Buy
59983 50MG ₹5282.6 Buy

Josamycin Chemical Properties,Uses,Production

Chemical Properties

Josamycin is a macrolide substance having antibacterial activity produced by the growth of Streptomyces narboensis var. josamyceticus.
Josamycin appears as white to yellowish white powder, slightly hygroscopic. Josamycin is very soluble in methanol or in ethanol, and very slightly soluble in water.

Uses

As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.
Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Definition

ChEBI: A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.

Pharmaceutical Applications

A naturally occurring antibiotic produced by Streptomyces narbonensis var. josamyceticus and belonging to the leucomycin group of macrolides. It is formulated for oral administration.
Many Gram-positive and Gram-negative anaerobes are susceptible, including Peptostreptococcus spp., Propionibacterium spp., Eubacterium spp. and Bacteroides spp.
After a single 1 g oral dose, a peak serum concentration of 2.74 mg/L was achieved 0.75 h after dosing. The AUC was 4.2 mg.h/L, and the apparent elimination half-life 1.5 h. Several inactive metabolites could be detected. It penetrates into saliva, tears and sweat, and achieves high levels in bile and lungs. It is mostly metabolized and excreted in the bile in an inactive form. Less than 20% of the dose appears in the urine, producing levels of around 50 mg/L.
The drug is generally well tolerated, producing only mild gastrointestinal disturbance. Its uses are similar to those of erythromycin. It is of limited availability.

Biological Activity

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Josamycin Preparation Products And Raw materials

Raw materials

Magnesium sulfate Starch Sodium hydroxide Hydrochloric acid Potassium Phosphate Dibasic
Sodium chloride SOYBEAN MEAL D-Glucose monohydrate
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Preparation Products

9-Deoxy-9-oxoleucomycin V 3-acetate 4''-O-(3-methylbutanoate)

Josamycin Suppliers

Global( 224)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10326 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +86-17531190177; +8617531190177 China 5959 58 Inquiry
Firsky International Trade (Wuhan) Co., Ltd +8615387054039 China 436 58 Inquiry
airuikechemical co., ltd. +undefined86-15315557071 China 983 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Hubei Ipure Biology Co., Ltd 58
Hebei Yanxi Chemical Co., Ltd. 58
Firsky International Trade (Wuhan) Co., Ltd 58
airuikechemical co., ltd. 58
Henan Tianfu Chemical Co.,Ltd. 55
Hangzhou FandaChem Co.,Ltd. 55

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16846-24-5(Josamycin)Related Search:

DL-CARNITINE Josamycin 2',9-dipropionate,Josamycin 9,2'-dipropionate,Josamycin dipropionate JOSAMYCIN EPY(CRM STANDARD) JOSAMYCIN PROPIONATE EPY(CRM STANDARD) JOSAMYCIN MM(CRM STANDARD)
JOSAMYCIN PROPIONATE Deisovaleryl josamycin E,E-8,10-DODECADIEN-1-YL ACETATE 4-(Dimethylamino)tetrahydro-2H-pyran 2-Ethylhexyloxypropylamine
Josamycin methyl 3-(acetoxy)octanoate 8,10-DODECADIEN-1-OL ISO-PROPYL-UNDECYLENATE ETHYL 3 ACETOXY HEXANOATE
DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER
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Vilprafen Wilprafen Josamycin Solution, 100ppm Josamycin for peak identification 3-Acetate 4B-(3-Methylbutanoate)leucoMycin V LeucoMycin V, 3-acetate4B-(3-Methylbutanoate) Leucomycin V 3-acetate 4''-(3-methylbutanoate) YL-704A3 3-acetate4(supb)-(3-methylbutanoate) C12662 Josamycin solution solution,1000ppm Josamycin solution JOSAMYCIN LEUCOMYCIN V,3-AC-ETA 4B-(3-METHYLBUTANOATE) LEUCOMYCIN V,3-ACETA 4BETA-(3-METHYL BUTANOATE) LEUCOMYCIN A3 antibioticyl-704a3 kitasamycina3 leucomycinv,3-acetate4(supb)-(3-methylbutanoate) turimycina5 EN 141 Iosalide Jomybel Josacine Josamina Leucomycin A3 (8CI) Leucomycin V, 3-acetate 4B-(3-methylbutanoate) (9CI) LEUCOMYCIN V,3-ACETA 4β-(3-METHYL BUTANOATE) Josamycin Standard Josamycin for peak identification CRS Josamycin CRS JOSAMYCIN USP/EP/BP (2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4- [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxa Pre-validation JOSAMYCIN(16846-24-5) (4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-6-[[3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methylbutanoyl)-α-L-ribo-hexopyranosyl]-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-10-hydroxy-5-methoxy-9,16-dimethyl-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-2-one (josamycin) Sparsentan Impurity 65 Leucomycin A3 (>90%) lucamycin 16846-24-5 C42H69NO15 BioChemical Antibiotics Antibiotics A to Z Antibiotics G-M Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Antibiotic Explorer A - KAntibiotics Antibacterial Antibiotics A to Antibiotics G-MAntibiotics Chemical Structure Class Interferes with Protein SynthesisAntibiotics