Mestinon
- CAS No.
- 101-26-8
- Chemical Name:
- Mestinon
- Synonyms
- PYRIDOSTIGMINE BROMIDE;PYBR;3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE;kalymin;regonal;kalimin;ro1-5130;mestinon;3-Hydroxy-1-;mestinonbromide
- CBNumber:
- CB9356274
- Molecular Formula:
- C9H13BrN2O2
- Molecular Weight:
- 261.12
- MOL File:
- 101-26-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:42
| Melting point | 154 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Very soluble in water and in ethanol (96 per cent). |
| form | Solid |
| color | White to Almost white |
| Merck | 14,7977 |
| BCS Class | 3 |
| InChIKey | VNYBTNPBYXSMOO-UHFFFAOYSA-M |
| CAS DataBase Reference | 101-26-8(CAS DataBase Reference) |
| EPA Substance Registry System | Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H317 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-43 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU5270000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2933399090 | |||||||||
| Toxicity | man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991. | |||||||||
| NFPA 704 |
|
Mestinon price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P9797 | Pyridostigmine bromide | 101-26-8 | 1G | ₹12719.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3120 | Pyridostigmine Bromide pharmaceutical secondary standard, certified reference material | 101-26-8 | 500MG | ₹16724.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9797 | Pyridostigmine bromide | 101-26-8 | 5G | ₹41254.08 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1339 | Pyridostigmine Bromide | 101-26-8 | 5G | ₹11800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1339 | Pyridostigmine Bromide | 101-26-8 | 25G | ₹19100 | 2022-05-26 | Buy |
Mestinon Chemical Properties,Uses,Production
Description
Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Chemical Properties
White Solid
Uses
Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.
General Description
Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.
Mestinon Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Global Calcium Pvt Ltd | +91-8050750904 +91-8040554500 | Karnataka, India | 132 | 58 | Inquiry |
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| Sami Sabinsa Group Limited (formerly Sami Labs Limited) | +91-8028397978 +91-9972587319 | Karnataka, India | 66 | 58 | Inquiry |
| Ruskin Chemipharm | 09820476680 | Mumbai, India | 22 | 58 | Inquiry |
| Ramkishore Chemical Company Pvt. Ltd. | 91-11-32952738 | Delhi, India | 165 | 58 | Inquiry |
| Meruvax Pharma (South Asia) | +91 917-735-9925 | Andhra Pradesh, India | 106 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| MAITHRI LABORATORIES PRIVATE LTD | New Delhi, India | 11 | 58 | Inquiry | |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
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