Rivastigmine
- CAS No.
- 123441-03-2
- Chemical Name:
- Rivastigmine
- Synonyms
- RIVASTIGMINE HYDROGEN TARTRATE;EXELON;Rivastigmine base;mine;Rivastig;cabalatine;Revastigmine;RIVASTIGMINE;RivastigiMine;S-RivastigMine
- CBNumber:
- CB8328151
- Molecular Formula:
- C14H22N2O2
- Molecular Weight:
- 250.34
- MOL File:
- 123441-03-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:27
| alpha | D20 -32.1° (c = 5 in ethanol) |
|---|---|
| Boiling point | 316.2±34.0 °C(Predicted) |
| Density | 1.038±0.06 g/cm3(Predicted) |
| Flash point | 145℃ |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Powder |
| pka | pKa 8.99 (Uncertain) |
| color | Colorless to light yellow |
| CAS DataBase Reference | 123441-03-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H411 |
| Precautionary statements | P264-P270-P273-P301+P310-P391-P405 |
| RIDADR | UN 2810 6.1 / PGIII |
| HS Code | 2924296000 |
Rivastigmine Chemical Properties,Uses,Production
Uses
Antidepressant
Definition
ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
General Description
Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease.
Pharmacokinetics
Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys.
Metabolism
Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds.
Rivastigmine Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| PSN Medicare Private Limited | +91-9030090313 +91-7702388996 | Telangana, India | 82 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Aarti Drugs Ltd | 08048372728Ext 357 | Maharashtra, India | 6 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
Related articles
- An AChE inhibitor---Rivastigmine
- Rivastigmine is a slowly reversible AChE inhibitor and BuChE inhibitor approved for use in mild-to-moderate AD Rivastigmine is....
- Apr 28，2022
123441-03-2(Rivastigmine)Related Search:
1of4
chevron_right