Neostigmine bromide
- CAS No.
- 114-80-7
- Chemical Name:
- Neostigmine bromide
- Synonyms
- Prostigmi;Neostigmin;Neoesserin;prostigmin;Neoserine);Juvastigmin;PROSTIGMINE;stigmosanbromide;stigmanolbromide;eustigminbromide
- CBNumber:
- CB3677212
- Molecular Formula:
- C12H19BrN2O2
- Molecular Weight:
- 303.2
- MOL File:
- 114-80-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/6 17:45:48
| Melting point | 175-177 °C(lit.) |
|---|---|
| Density | 1.4344 (rough estimate) |
| refractive index | 1.5410 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 1 g/mL |
| form | powder |
| color | white |
| PH | 5.2～6.2 (100g/l, 25℃) |
| Water Solubility | 1 g/ mL |
| Merck | 14,6464 |
| BCS Class | 3 |
| EPA Substance Registry System | Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (114-80-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+,T | |||||||||
| Risk Statements | 26/27/28-36/37/38-42/43-25 | |||||||||
| Safety Statements | 22-26-36/37/39-45-37/39-28A | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BR3150000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
Neostigmine bromide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N2001 | Neostigmine bromide ≥98% (HPLC and titration), powder | 114-80-7 | 1G | ₹10370.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N2001 | Neostigmine bromide ≥98% (HPLC and titration), powder | 114-80-7 | 5G | ₹23230.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N2001 | Neostigmine bromide ≥98% (HPLC and titration), powder | 114-80-7 | 10G | ₹52035.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0358 | Neostigmine Bromide | 114-80-7 | 5G | ₹6800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0358 | Neostigmine Bromide | 114-80-7 | 25G | ₹10100 | 2022-05-26 | Buy |
Neostigmine bromide Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:
- to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
- to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
- to study its effects on depolarization of bag cell neurons.
General Description
Neostigmine bromide, (m-hydroxyphenyl)trimethylammonium bromide dimethylcarbamateor the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniumbromide (Prostigmin bromide), is usedas an antidote to nondepolarizing neuromuscular blockingdrugs and in the treatment of myasthenia gravis. It occurs asa bitter, odorless, white, crystalline powder. It is soluble inwater and alcohol. The crystals are much less hygroscopicthan those of neostigmine methylsulfate and thus may beused in tablets. Solutions are stable and may be sterilized byboiling. Aqueous solutions are neutral to litmus.
Clinical Use
Use of physostigmine, as a prototype of an indirect-actingparasympathomimetic drug, facilitated the development ofstigmine, in which a trimethylamine group was placed para toa dimethylcarbamate group in benzene. Better inhibition ofcholinesterase was observed when these groups were placedmeta to each other as in neostigmine, a more active and usefulagent. Although physostigmine contains a methylcarbamatefunctional group, greater chemical stability towardhydrolysis was obtained with the dimethylcarbamyl group inneostigmine.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br-, NH3, and NOx. See also CARBAMATES and BROMIDES.
Purification Methods
Crystallise neostigmine bromide from EtOH/diethyl ether. Its solubility in H2O is ~50%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) The starting material 3-dimethylcarbamoyl-N,N-dimethylaniline [59-99-4] has b 195o/20mm [Beilstein 13 III 936], and its picrate has m 138o (from EtOH).
Neostigmine bromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vanquest Pharma Pvt Ltd | +91-9920897640 +91-9920897640 | Mumbai, India | 36 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Mac Chem Products (India) Pvt Ltd (Naprod Group) | +91-9727753234 +91-7770016606 | Maharashtra, India | 37 | 58 | Inquiry |
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shaivya Pharmachem. | 08048371708Ext 729 | Gujarat, India | 56 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |