Xylazine Hydrochloride
- CAS No.
- 23076-35-9
- Chemical Name:
- Xylazine Hydrochloride
- Synonyms
- XYLAZINE HCL;XYLAZIN HYDROCHLORIDE;2-(2,6-DIMETHYLPHENYLAMINO)-5,6-DIHYDRO-4H-THIAZINE HYDROCHLORIDE;N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazine-2-aminehydrochloride;rompun;celactal;Rompun[R];245-417-0;bay-va1470;xylazinechloride
- CBNumber:
- CB3477355
- Molecular Formula:
- C12H17ClN2S
- Molecular Weight:
- 256.79
- MOL File:
- 23076-35-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 150-164?C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | ≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O |
| form | Solid |
| color | White to Almost white |
| Water Solubility | Soluble in water |
| Merck | 14,10080 |
| BRN | 6448471 |
| InChI | InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H |
| InChIKey | QYEFBJRXKKSABU-UHFFFAOYSA-N |
| SMILES | N(C1SCCCN=1)C1C(=CC=CC=1C)C.Cl |
| CAS DataBase Reference | 23076-35-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | XJ0776350 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | dog,LD50,intramuscular,47mg/kg (47mg/kg),Clinical Toxicology. Vol. 15, Pg. 281, 1979. | |||||||||
| NFPA 704 |
|
Xylazine Hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | X1251 | Xylazine hydrochloride ≥99.0% (HPLC) | 23076-35-9 | 1G | ₹6592.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | X1251 | Xylazine hydrochloride ≥99.0% (HPLC) | 23076-35-9 | 5G | ₹21011.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46995 | Xylazine hydrochloride VETRANAL?, analytical standard | 23076-35-9 | 100MG | ₹5780.55 | 2022-06-14 | Buy |
| TCI Chemicals (India) | X0059 | Xylazine Hydrochloride | 23076-35-9 | 5G | ₹7400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | X0059 | Xylazine Hydrochloride | 23076-35-9 | 25G | ₹13900 | 2022-05-26 | Buy |
Xylazine Hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Xylazine Hydrochloride is an alpha-2 agonist with sedative, analgesic, and muscle relaxant properties. It is approved for use in dogs,cats,horses,deer,and elk. This agent causes vomiting in a large percentage of cats and in some dogs. Xylazine is antagonized by yohimbine. It produces effective analgesia in horses and is often used for treating the pain associated with colic and for sedation for minor procedures.It is also used in combination with ketamine for short-term feld procedures in horses,such as castration and suturing of extensive wounds，because this combination usually produces 15 to 20 minutes of recumbency. Extralabel use of xylazine for cesarean sections in cattle and other surgical procedures is common. Xylazine Hydrochloride is used in cats and dogs as a tranquilizer and in combination with other injectable agents for surgical procedures.
Definition
ChEBI: Xylazine hydrochloride is the hydrochloride salt of xylazine. It is used as a sedative, analgesic, and muscle relaxant in veterinary medicine. It has a role as an alpha-adrenergic agonist, an analgesic, an emetic, a muscle relaxant and a sedative. It contains a xylazine(1+).
Biological Activity
Xylazine Hydrochloride is a strong agonist of α2-adrenoceptor [1].xylazine hcl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mm) [2]. in the analgesic testing, xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. in addition, xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the ic50 value of 18nm. furthermore, xylazine has displayed a potent specific [3h]-dihydromorphine binding inhibition with the ic50 value of 8μm in opiate receptor binding test [1].
Side effects
Respiratory depression, low blood pressure, slowed heart rate, hypothermia, pupil constriction and, sometimes, high blood sugar levels.
The pupil constriction and respiratory depression are particularly of concern, as these are very common and widely understood effects of an opioid overdose.
Severe, necrotic skin ulcerations are the most striking side effect of xylazine. Notably, while these skin ulcerations may appear at the site of injection, they may appear at a completely different site on the body altogether. Soft tissue infections are often associated with IV drug use of more conventional illicit substances such as opioids, but these are almost always located at the injection site.
Veterinary Drugs and Treatments
Xylazine Hydrochloride is approved for use in dogs, cats, horses, deer, and elk. It is indicated in dogs, cats, and horses to produce a state of sedation with a shorter period of analgesia, and as a preanesthetic before local or general anesthesia. Because of the emetic action of xylazine in cats, it is occasionally used to induce vomiting after ingesting toxins.
Xylazine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NGL Fine Chem limited | +91-8866366396 +91-8866366396 | Mumbai, India | 26 | 58 | Inquiry |
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
| Manasvi Life Sciences | +91-9391326151 +91-9490072008 | Hyderabad, India | 39 | 58 | Inquiry |
| Alivira Animal Health Ltd | +91-8976959415 +91-9920774050 | Maharashtra, India | 35 | 58 | Inquiry |
| Noven Lifesciences Pvt Limited | +91-9030209898 +91-9848878833 | Telangana, India | 21 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Festiva Pharma | 08048372775Ext 728 | Gujarat, India | 238 | 58 | Inquiry |
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