Thiamethoxam
- CAS No.
- 153719-23-4
- Chemical Name:
- Thiamethoxam
- Synonyms
- Thiametoxam;Actara;hiamethoxam;Thiomethoxam;3-(2-CHLORO-5-THIAZOLYLMETHYL)TETRAHYDRO-5-METHYL-N-NITRO-4H-1,3,5-OXADIAZIN-4-IMINE;Adage;Cruiser;Adage 5fs;Actara 2gr;Ccris 9026
- CBNumber:
- CB5105069
- Molecular Formula:
- C8H10ClN5O3S
- Molecular Weight:
- 291.71
- MOL File:
- 153719-23-4.mol
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 139.1° |
|---|---|
| Boiling point | 485.8±55.0 °C(Predicted) |
| Density | 1.71±0.1 g/cm3(Predicted) |
| vapor pressure | 6.6 x 10-9 Pa (25 °C) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: 250 mg/mL (857.02 mM) |
| form | Solid |
| Water Solubility | 4.1 x 103 mg l-1 (25 °C) |
| pka | 0.99±0.10(Predicted) |
| color | Off-white to yellow |
| BRN | 8491021 |
| InChI | InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3 |
| InChIKey | NWWZPOKUUAIXIW-DHZHZOJOSA-N |
| SMILES | O1CN(C)C(=N[N+]([O-])=O)N(CC2SC(Cl)=NC=2)C1 |
| LogP | -0.13 at 25℃ |
| EPA Substance Registry System | Thiamethoxam (153719-23-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-50/53 | |||||||||
| Safety Statements | 22-61-60 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29341000 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 1563 orally, >2000 dermally; LD50 in bobwhite quail, mallard duck (mg/kg): 1552, 576 orally. LC50 (96hr) in rainbow trout, bluegill (mg/l): >100, >114 (Senn). | |||||||||
| NFPA 704 |
|
Thiamethoxam Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Yellow Solid
Uses
Thiamethoxam is a broad spectrum insecticide active against a wide spectrum of sucking and chewing insect pests after foliar, soil or seed treatment.
Definition
ChEBI: Thiamethoxam is an oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively. It has a role as an antifeedant, a carcinogenic agent, an environmental contaminant, a xenobiotic and a neonicotinoid insectide. It is an oxadiazane, a member of 1,3-thiazoles, an organochlorine compound and a 2-nitroguanidine derivative. It derives from a 2-chlorothiazole.
Application
Thiamethoxam is a neonicotinoid insecticide that is used widely in Wisconsin. Thiamethoxam is the active ingredient in a variety of products used in agriculture to kill sucking and chewing insects that feed on roots, leaves, and other plant tissues. Agricultural uses include soil and seed treatments as well as leaf spraying for most row and vegetable crops like corn, soybeans, snap beans, and potatoes. It is also used to control insects in livestock pens, poultry houses, sod farms, golf courses, lawns, household plants, and tree nurseries. It was first registered by the U.S. Environmental Protection Agency in 1999. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens.
Metabolic pathway
All the information on thiamethoxam is taken from a summary of the proceedings of meeting published by the manufacturer. Full experimental details are not given in the report and the identity of metabolites is not disclosed (Novartis, 1997).
Mode of action
Thiamethoxam interferes with nicotinic acetylcholine receptors in the insect’s nervous system, which are essential for proper functioning of the nerves. Within hours of contact or ingestion of thiamethoxam, insects stop feeding. Death usually occurs within 24 to 48 hours.
The activity of thiamethoxam, or any insecticide, at the target site is just one factor in its efficacy. When comparing insecticides, other variables – including how the compound interacts with the environment, the plant and the insect – also contribute to its insecticidal mode of action.
The Insecticide Resistance Action Committee (IRAC) has organized insecticides into 28 groups, plus sub-groups, based on their modes of action. Thiamethoxam is a Group 4A insecticide (neonicotinoids).
Thiamethoxam Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| India Pesticides Limited | +91-5222653602 +91-5222653602 | Uttar Pradesh, India | 12 | 58 | Inquiry |
| Crop Life Science Limited | +91-7940373967 +91-7926872996 | Gujarat, India | 21 | 58 | Inquiry |
| Spectrum Ethers Ltd | +91-2226054452 +91-2226487769 | Maharashtra, India | 5 | 58 | Inquiry |
| Bharat Rasayan | +91-9619772584 +91-9619772584 | Maharashtra, India | 23 | 58 | Inquiry |
| Insecticides Ltd | +91-1127679700 +91-1127679700 | New Delhi, India | 13 | 58 | Inquiry |
| Kilpest India limited | +91-7552586536 +91-7552586536 | Madhya Pradesh, India | 38 | 58 | Inquiry |
| Indofil Industries Limited | +91-2266637373 +91-2266637373 | Maharashtra, India | 16 | 58 | Inquiry |
| General Crop Science | +91-9810438260 +91-9896700555 | Haryana, India | 31 | 58 | Inquiry |
| Unique Farm Aid Pvt Ltd | +91-9873006591 +91-9873006592 | New Delhi, India | 31 | 58 | Inquiry |
| Bhagiradha Chemicals And Industries Limited | +91-4042212323 +91-4042221212 | Telangana, India | 12 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| India Pesticides Limited | 58 |
| Crop Life Science Limited | 58 |
| Spectrum Ethers Ltd | 58 |
| Bharat Rasayan | 58 |
| Insecticides Ltd | 58 |
| Kilpest India limited | 58 |
| Indofil Industries Limited | 58 |
| General Crop Science | 58 |
| Unique Farm Aid Pvt Ltd | 58 |
| Bhagiradha Chemicals And Industries Limited | 58 |
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