Hydrochlorothiazide
- CAS No.
- 58-93-5
- Chemical Name:
- Hydrochlorothiazide
- Synonyms
- HYDROCHLORTHIAZIDE;HCTZ;Dyazide;Hydrochlorothiazid;Dihydrochlorothiazide;Ziac;Zide;Oretic;roxane;Esimil
- CBNumber:
- CB5383966
- Molecular Formula:
- C7H8ClN3O4S2
- Molecular Weight:
- 297.74
- MOL File:
- 58-93-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 273 °C |
|---|---|
| Boiling point | 577.0±60.0 °C(Predicted) |
| Density | 1.6761 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides |
| pka | 7.9, 9.2(at 25℃) |
| form | solid |
| color | White to Off-White |
| Odor | wh. or pract. wh. cryst. powd., odorless |
| Water Solubility | 722mg/L(25 ºC) |
| λmax | 318nm(H2O)(lit.) |
| Merck | 14,4781 |
| BRN | 625101 |
| BCS Class | 3,4 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | JZUFKLXOESDKRF-UHFFFAOYSA-N |
| LogP | -0.070 |
| CAS DataBase Reference | 58-93-5(CAS DataBase Reference) |
| IARC | 2B (Vol. 50, 108) 2016 |
| NIST Chemistry Reference | 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide(58-93-5) |
| EPA Substance Registry System | Hydrochlorothiazide (58-93-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xi,T,F,Xn | |||||||||
| Risk Statements | 22-42/43-36/38-23/25-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-24-36/37-45-33-16-7-36/37/39-27-26 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DK9100000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 590 i.v.; >8000 orally (Piala) | |||||||||
| NFPA 704 |
|
Hydrochlorothiazide price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H4759 | Hydrochlorothiazide crystalline | 58-93-5 | 5G | ₹4524.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H4759 | Hydrochlorothiazide crystalline | 58-93-5 | 25G | ₹5715.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1032 | Hydrochlorothiazide Pharmaceutical Secondary Standard; Certified Reference Material | 58-93-5 | 1G | ₹9590.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H4759 | Hydrochlorothiazide crystalline | 58-93-5 | 100G | ₹18456.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H2910 | Hydrochlorothiazide meets USP testing specifications | 58-93-5 | 5G | ₹2966.05 | 2022-06-14 | Buy |
Hydrochlorothiazide Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Labelled Hydrochlorothiazide (H714560). Hydrochlorothiazide is a carbonic anhydrase inhibitor as a diuretic.
Definition
ChEBI: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
General Description
Crystals or white powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Strong reducing agents will produce toxic gases ammonia and hydrogen sulfide.
Fire Hazard
Flash point data for Hydrochlorothiazide are not available but Hydrochlorothiazide is probably combustible.
Safety Profile
Poison bp intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: sodum level changes, chlorine level changes, acute pulmonary edema, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A duetic. When heated to decomposition it emits very toxic fumes of SOx, Cl-, and NOx.
Hydrochlorothiazide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 580)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Molkem Chemicals | +91-917228022464 +91-7228022464 | Ahmedabad, India | 138 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| CTX Lifesciences Pvt Ltd | +91-2612399669 +91-7434851395 | Gujarat, India | 28 | 58 | Inquiry |
| Unichem Laboratories Ltd | +91-2266888333 +91-2266888333 | Maharashtra, India | 62 | 58 | Inquiry |
| SNJ Labs Pvt Ltd | +91-9033216399 +91-9824296655 | Gujarat, India | 17 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Molkem Chemicals | 58 |
| HEMA PHARMACEUTICALS PVT LTD | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Ipca Laboratories Ltd | 58 |
| CTX Lifesciences Pvt Ltd | 58 |
| Unichem Laboratories Ltd | 58 |
| SNJ Labs Pvt Ltd | 58 |
| Lakshmi Farmachem | 58 |
| Alembic Pharmaceuticals Limited | 58 |
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Hydrochlorothiazide Impurity
Hydrochlorothiazide IMP
6-Chloro-7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
HYDROCHLOROTHIAZIDE USP
HYDROCHLOROTHIAZIDE CARBONIC ANHYDRASE I N
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