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Anacetrapib

CAS No.: 875446-37-0

Chemical Name:: Anacetrapib

Synonyms: CS-66;Mk0859;Mk-0859;Anacetrapib;Anacetripib;Timapiprant;Unii-p7T269pr6s;Anacetrapib 13C6;Anacetrapib, >=99%;Anacetrapib(MK0859)

CBNumber:: CB62487713

Molecular Formula:: C30H25F10NO3

Molecular Weight:: 637.51

MOL File:: 875446-37-0.mol

Modify Date:: 2024/7/2 8:55:13

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Anacetrapib Properties

Boiling point	555.3±50.0 °C(Predicted)
Density	1.345
storage temp.	Store at -20°C
solubility	≥31.9 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
form	solid
pka	-2.30±0.60(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335-H302-H319

Precautionary statements

P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

NFPA 704

	0
2		0

Anacetrapib Chemical Properties,Uses,Production

Uses

An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.

Enzyme inhibitor

This cholesteryl ester transfer protein (or CETP) inhibitor (FW = 637.51 g/mol; CAS 875446-37-0), also known by the code name MK-0859, reduces plasma cholesterol concentrations, thereby increasing serum highdensity lipoprotein levels and preventing cardiovascular disease associated with hypercholesteremia. X-ray crystal studies suggest that CETP is a crescent-shaped protein with a 6-nm hydrophobic tunnel traversing its core Both of the tunnel’s two entrances face the protein’s concave surface, which most likely is the interaction platform for binding HDL particles and engaging its lipoprotein constituents. CETP mediates the reciprocal transfer of neutral lipids (e.g., cholesteryl esters and triglycerides) and phospholipids between different lipoprotein fractions in blood plasma. Anacetrapib is unlike many CETP inhibitors, which increase systolic blood pressure. Anacetrapib also exhibits a low-to-moderate degree of absorption after oral dosing and majority of the absorbed dose is eliminated via oxidation to a series of hydroxylated metabolites that undergo conjugation with glucuronate before excretion into bile. Unlike torcetrapib, another CETP inhibitor, anacetrapib does not elevate blood pressure, alter electrolytes, or cause any significant side effects.

Anacetrapib Preparation Products And Raw materials

Raw materials

4'-FLUORO-2'-METHOXY-5'-ISOPROPYL-4-TRIFLUOROMETHYL-1,1'-BIPHENYL-2-METHANOL 2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-, (4S,5R)-

Preparation Products

Anacetrapib Suppliers

Global( 192)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Seasons Biotechnology Co., Ltd.	+86-0576-89232655 +86-13566878689	China	47	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	China	12453	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29897	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Seasons Biotechnology Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58

Anacetrapib Spectrum

Anacetrapib(875446-37-0)¹HNMR

875446-37-0(Anacetrapib)Related Search:

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5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

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(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)-4-methyl-1,3-oxazolidin-2-one Anacetrapib Mk0859 Mk-0859 Unii-p7T269pr6s (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one Anacetrapib(MK0859) 2-Oxazolidinone, 5-[3,5-bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-2'-Methoxy-5'-(1-Methylethyl)-4-(trifluoroMethyl)[1,1'-biphenyl]-2-yl]Methyl]-4-Methyl-, (4S,5R)- (4S,5R)-5-[3,5-Bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-2'-Methoxy-5'-(1-Methylethyl)-4-(trifluoroMethyl)[1,1'-biphenyl]-2-yl]Methyl]-4-Methyl-2-oxazolidinone (4S,5R)-5-[3,5-Bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-Methoxy-4 (4S,5R)-5-(3,5-bis(trifluoroMethyl)phenyl)-3-((4'-fluoro-2'-Methoxy-4-(trifluoroMethyl)-[1,1'-biphenyl]-2-yl)Methyl)-4-Methyloxazolidin-2-one (4S,5R)-5-(3,5-bis(trifluoroMethyl)phenyl)-3-((4-fluoro-5-isopropyl-2-Methoxy-4-(trifluoroMethyl)-[1,1-biphenyl]-2- Anacetripib (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one Anacetrapib (MK-0859) (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4-methyl-1,3-oxazolidin-2-one EZSolution Anacetrapib Anacetrapib, >=99% Timapiprant (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5- MK0859; MK-0859; MK 0859; ANACETRAPIB CS-66 MK-0859; MK 0859; MK0859 Anacetrapib USP/EP/BP (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-... Anacetrapib 13C6 TIANFUCHEM-- Anacetrapib (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-5-isopropyl-2-methoxy-phenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-oxazolidin-2-one (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one 875446-37-0 C30H25F10NO3 Inhibitor CETP inhibitor Aromatics Chiral Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Anacetrapib