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PF-04457845

PF-04457845 Structure
CAS No.
1020315-31-4
Chemical Name:
PF-04457845
Synonyms
CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
CBNumber:
CB62522724
Molecular Formula:
C23H20F3N5O2
Molecular Weight:
455.43
MOL File:
1020315-31-4.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

PF-04457845 Properties

Boiling point 687.0±55.0 °C(Predicted)
Density 1.389±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
pka 12.72±0.20(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

WGK Germany  3

PF-04457845 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0184 PF-04457845 ≥98% (HPLC) 1020315-31-4 5MG ₹10792.53 2022-06-14 Buy
Sigma-Aldrich(India) PZ0184 PF-04457845 ≥98% (HPLC) 1020315-31-4 25MG ₹43505.68 2022-06-14 Buy
Product number Packaging Price Buy
PZ0184 5MG ₹10792.53 Buy
PZ0184 25MG ₹43505.68 Buy

PF-04457845 Chemical Properties,Uses,Production

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

PF-04457845 Preparation Products And Raw materials

Raw materials

Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1) Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester CarbaMic acid, N-3-pyridazinyl-, phenyl ester BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)-
3-Hydroxybenzyl alcohol 2-Chloro-5-trifluoromethylpyridine
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Preparation Products

PF-04457845 Suppliers

Global( 70)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10978 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
LEAPCHEM CO., LTD. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58
N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide PF-04457845 N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide PF-04457845;PF04457845 1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]- N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide CS-1549 PF-04457845 >=98% (HPLC) Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor 1020315-31-4 C23H20F3N5O2