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PF-04457845

PF-04457845 Structure
  • ₹10792.53 - ₹43505.68
  • Product name: PF-04457845
  • CAS: 1020315-31-4
  • MF: C23H20F3N5O2
  • MW: 455.43
  • EINECS:
  • MDL Number:MFCD18782721
  • Synonyms:N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;PF-04457845;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;PF-04457845;PF04457845;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;CS-1549;PF-04457845 >=98% (HPLC)
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0184
  • Product descriptionPF-04457845 ≥98% (HPLC)
  • Packaging5MG
  • Price₹10792.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0184
  • Product descriptionPF-04457845 ≥98% (HPLC)
  • Packaging25MG
  • Price₹43505.68
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0184 PF-04457845 ≥98% (HPLC) 5MG ₹10792.53 2022-06-14 Buy
Sigma-Aldrich(India) PZ0184 PF-04457845 ≥98% (HPLC) 25MG ₹43505.68 2022-06-14 Buy

Properties

Boiling point :687.0±55.0 °C(Predicted)
Density :1.389±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
pka :12.72±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

PF-04457845 is an orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 7.2 nM) that is selective against other serine hydrolases. It is a covalent inhibitor that carbamylates the active site serine nucleophile of FAAH. In a rat model of inflammatory pain, oral administration of 0.1 mg/kg PF-04457845 has been shown to reduce inflammatory pain with efficacy comparable to that of naproxen.