(±)-JQ1
![(±)-JQ1 Structure](CAS/20180808/GIF/1268524-69-1.gif)
- CAS No.
- 1268524-69-1
- Chemical Name:
- (±)-JQ1
- Synonyms
- rac JQ-1;(+/-)-JQ1;(+/-)-SGCBD01;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
- CBNumber:
- CB62589817
- Molecular Formula:
- C23H25ClN4O2S
- Molecular Weight:
- 456.99
- MOL File:
- 1268524-69-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:32
Boiling point | 610.4±65.0 °C(Predicted) |
---|---|
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: soluble2mg/mL, clear (warmed) |
pka | 2.05±0.60(Predicted) |
form | powder |
color | white to beige |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
(±)-JQ1 price More Price(2)
(±)-JQ1 Chemical Properties,Uses,Production
Uses
(±)-JQ1 has been used to study its effect on adipogenesis, by analysing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B. JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN′s substrate recruiting function in mouse and human.
Biochem/physiol Actions
(±)-JQ1 is a Brd4 inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.
(±)-JQ1 Preparation Products And Raw materials
Raw materials
Preparation Products
(±)-JQ1 Suppliers
Global( 24)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13187 | 58 | Inquiry |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
Energy Chemical | 021-58432009 400-005-6266 | China | 44843 | 58 | Inquiry |
Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | China | 4394 | 58 | Inquiry |
Nanjing Shizhou Biology Technology Co.,Ltd | 18351873721 | China | 8298 | 58 | Inquiry |
Taizhou Tongxin Bio-Tech Co., Ltd | 0523-18601685-898 18652728585 | China | 2790 | 60 | Inquiry |
Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | China | 3058 | 58 | Inquiry |
1268524-69-1((±)-JQ1)Related Search:
[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester
tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
(+/-)-SGCBD01
rac JQ-1
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester
(+/-)-JQ1
tert-butyl
2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11
,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1
2-pentaen-9-yl]acetate
1268524-69-1