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(±)-JQ1

(±)-JQ1 Structure
  • ₹20080.38 - ₹81479.78
  • Product name: (±)-JQ1
  • CAS: 1268524-69-1
  • MF: C23H25ClN4O2S
  • MW: 456.99
  • EINECS:
  • MDL Number:MFCD23726614
  • Synonyms:[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+/-)-SGCBD01;rac JQ-1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;(+/-)-JQ1;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0974
  • Product description(+/-)-JQ1 ≥98% (HPLC)
  • Packaging5MG
  • Price₹20080.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0974
  • Product description(+/-)-JQ1 ≥98% (HPLC)
  • Packaging25MG
  • Price₹81479.78
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0974 (+/-)-JQ1 ≥98% (HPLC) 5MG ₹20080.38 2022-06-14 Buy
Sigma-Aldrich(India) SML0974 (+/-)-JQ1 ≥98% (HPLC) 25MG ₹81479.78 2022-06-14 Buy

Properties

Boiling point :610.4±65.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :2.05±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

(±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by (±) JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.1 Chiral version is available for purchase (Cat#10-1584).

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