INCB8761(PF-4136309)

CAS No.: 1341224-83-6

Chemical Name:: INCB8761(PF-4136309)

Synonyms: CS-1440;EOS-61910;NCB8761(PF-4136309);INCB8761(PF-4136309);PF-04136309(INCB-8761);ZNSVOHSYDRPBGI-LXWOLXCRSA-N;N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL);INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761;INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309;N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide

CBNumber:: CB62627975

Molecular Formula:: C29H31F3N6O3

Molecular Weight:: 568.59

MOL File:: 1341224-83-6.mol

Modify Date:: 2023/6/8 9:02:51

Request For Quotation

INCB8761(PF-4136309) Properties

Boiling point	712.2±60.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml)
form	solid
pka	13.17±0.46(Predicted)
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

HS Code

2933998090

NFPA 704

	0
2		0

INCB8761(PF-4136309) Chemical Properties,Uses,Production

Description

PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC₅₀s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively). It also inhibits the voltage-gated potassium channel subtype K_v11.1 by 35% when used at a concentration of 10 μM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC₅₀ value of 3.9 nM.

Uses

PF 4136309 is a CCR5 receptor antagonists that contributes to the treatment of rheumatoid arthritis.

INCB8761(PF-4136309) Preparation Products And Raw materials

Raw materials

8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone 8-(5-(pyrimidin-2-yl)pyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol 2-[3-(Trifluoromethyl)benzoyl]aminoacetic acid Benzamide, N-[2-[(3S)-3-amino-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-, hydrochloride (1:1)

2,5-Dibromopyridine 1,4-Dioxaspiro[4.5]decan-8-one

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Preparation Products

INCB8761(PF-4136309) Suppliers

Global( 88)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20308	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Suzhou ARTK Medchem Co., Ltd.	+8618168183658	China	39009	58	Inquiry

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Suzhou ARTK Medchem Co., Ltd.	58

1341224-83-6(INCB8761(PF-4136309))Related Search:

Adapalene Vorinostat (+)-Camptothecin 17-AAG

INCB8761(PF-4136309) NCB8761(PF-4136309) PF-04136309(INCB-8761) Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)- EOS-61910 N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide ZNSVOHSYDRPBGI-LXWOLXCRSA-N N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL) CS-1440 INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761 N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309 1341224-83-6