ChemicalBook > Product Catalog >Biochemical Engineering >Nucleoside drugs >Nucleotides and their analogs >3-ISOBUTYL-1-METHYLXANTHINE
3-ISOBUTYL-1-METHYLXANTHINE
- CAS No.
- 28822-58-4
- Chemical Name:
- 3-ISOBUTYL-1-METHYLXANTHINE
- Synonyms
- IBMX;MIX;3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione;IMX;SC 2964;NSC 165960;IBMX(NSC165960;3-Isobutyl-1-methylx;Isobutylmethylxanthine;Methylisobutylxanthine
- CBNumber:
- CB6263892
- Molecular Formula:
- C10H14N4O2
- Molecular Weight:
- 222.24
- MOL File:
- 28822-58-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/15 21:27:52
| Melting point | 200-201 °C(lit.) |
|---|---|
| Boiling point | 363.42°C (rough estimate) |
| Density | 1.2042 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: 1 M with gentle warming |
| form | powder |
| pka | 8.61±0.70(Predicted) |
| color | off-white |
| BRN | 247859 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| CAS DataBase Reference | 28822-58-4(CAS DataBase Reference) |
3-ISOBUTYL-1-METHYLXANTHINE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I7018 | 3-Isobutyl-1-methylxanthine ≥99%, BioUltra | 28822-58-4 | 100MG | ₹10088.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I7018 | 3-Isobutyl-1-methylxanthine ≥99%, BioUltra | 28822-58-4 | 250MG | ₹20102.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I5879 | 3-Isobutyl-1-methylxanthine ≥99% (HPLC), powder | 28822-58-4 | 100MG | ₹4947.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I5879 | 3-Isobutyl-1-methylxanthine ≥99% (HPLC), powder | 28822-58-4 | 250MG | ₹9829.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I7018 | 3-Isobutyl-1-methylxanthine ≥99%, BioUltra | 28822-58-4 | 1G | ₹55835.35 | 2022-06-14 | Buy |
3-ISOBUTYL-1-METHYLXANTHINE Chemical Properties,Uses,Production
Chemical Properties
White Needles with Yellow Cast
Uses
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
General Description
3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases. IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research. In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes.
Biological Activity
Phosphodiesterase inhibitor (IC 50 values are 13, 18, 19, 32 and 50 μ M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α -adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC 50 = 1.3 μ M).
Purification Methods
Recrystallise it from aqueous EtOH. [Beilstein 26
3-ISOBUTYL-1-METHYLXANTHINE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 257)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29791 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29884 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39894 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49374 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32080 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34553 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Merck Ltd | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| career henan chemical co | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
28822-58-4(3-ISOBUTYL-1-METHYLXANTHINE)Related Search:
Verofylline
3-ISOBUTYL-1-METHYLXANTHINE
Cipamfylline
8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE
1-METHYLXANTHINE
Mexafylline
8-Dicyclopropylmethyl-3-isobutyl-1-methylxanthine
8-Phenyl-3-isobutyl-1-methylxanthine
IBMX (3-Isobutyl-1-methylxanthine)
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3,7-Dihydro-1-methyl-3-(2-methy
3-isobutyl-1-methyl-1H-purine-2,6(3H,9H)-dione
3-isobutyl-1-methyl-3,9-dihydro-1H-purine-2,6-dione
3-isobutyl-1-methyl-7H-purine-2,6-dione
3-isobutyl-1-methyl-7H-purine-2,6-quinone
3-Isobutyl-1-methyxanthine
3-isobutyl-1-methyl-7H-xanthine
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
3-ISOBUTYL-1-METHYL-2,6(1H,3H)-PURINEDIONE
3-ISOBUTYL-1-METHYLXANTHINE
3-ISOBUTYL-I-METHYLXANTHINE
3-ISOBUTYL-1-METHYLXANTHINE SIGMAULTRA
Isobutyl-1-methylxanthine
3-ISOBUTYL-1-METHYLXANTHINE,ULTRAPURE
3-Isobutyl-1-methylxanthine, HPLC 99%
3-ISOBUTYL-1-METHYLXANTHINE (CRYSTALLINE)
3,9-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
NSC 165960
3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione
3-Isobutyl-1-methylxanthine 99+%
3-Isobutyl-1-methylxanthine,1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
3-Isobutyl-1-methylx
(3-isobutyl-1-Methylxanthine,IBMX)
3-Isobutyl-1-Methylxanthine, 99+% 1GR
3,9-Dihydro-1-Methyl-3-(2-Methylpropyl)-
3-Isobutyl-1-Methyl-1H-purine-2,6(3H,7H)-dione
1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-
3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-6-dione
3-Isobutyl-1-methylanxthine
3-isobutyl-1-methyl-xanthin
IMX
Isobutylmethylxanthine
Methylisobutylxanthine
SC 2964
Xanthine, 3-Isobutyl-1-methyl-
1-METHYL-3-ISOBUTYL XANTHINE
1-Methyl-3-isobutylxanthine
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
IBMX
MIX
3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem
IBMX(NSC165960
IMX; ISOBUTYLMETHYLXANTHINE; METHYLISOBUTYLXANTHINE; NSC165960; SC2964
1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-
3-ISOBUTYL-1-METHYLXANTHINE USP/EP/BP
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
MIX
IBMX
IBMX,Phosphodiesterase (PDE),inhibit,Inhibitor
3-isobutyl-1-methyl-9H-purine-2,6-dione
28822-58-4
Non-specific inhibitor of cAMP and cGMP phosphodiesterases.
KETONE
BioChemical
Chiral Building Blocks
Cell Biology
Cell Signaling and Neuroscience
Asymmetric Synthesis
G Proteins and Cyclic Nucleotides
Cyclic Nucleotide Metabolism