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Cinacalcet Impurity D

CAS No.: 1271930-15-4

Chemical Name:: Cinacalcet Impurity D

Synonyms: Cinacalcet USP RC B;CicalcetImpurity1HCl;CicalcetImpurityDHCl;cinacalcet iMpurity 8;Cinacalcet Impurity D;Cinacalcet Impurity D HCL;Cinacalcet tertiary amine;Cinacalcet USP Related Compound B;Cinacalcet Hydrochloride iMpuritX;Cinacalcet Impurity 5(Cinacalcet USP RC B)

CBNumber:: CB62671079

Molecular Formula:: C32H31F6N

Molecular Weight:: 543.59

MOL File:: 1271930-15-4.mol

Modify Date:: 2023/9/7 13:41:17

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Cinacalcet Impurity D Properties

Boiling point	552.2±50.0 °C(Predicted)
Density	1.203±0.06 g/cm3(Predicted)
pka	8.40±0.50(Predicted)
InChIKey	BMWNEBVDXWCUKG-CRPMJUFNNA-N
SMILES	C(N([C@@H](C1=C2C(C=CC=C2)=CC=C1)C)CCCC1=CC=CC(C(F)(F)F)=C1)CCC1=CC=CC(C(F)(F)F)=C1 \|&1:2,r\|

Cinacalcet Impurity D Chemical Properties,Uses,Production

Description

Cinacalcet Impurity D is a potential byproduct or impurity in the synthesis of the drug. It is essential to study the properties and potential implications of Cinacalcet Impurity D for pharmaceutical research. Cinacalcet is a drug commonly used for the treatment of hyperparathyroidism in patients with chronic kidney disease.

Uses

N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet (Cinacalcet USP Related Compound B) is an impurity of Cinacalcet Hydrochloride (C441800). Cinacalcet is used in clinical trial in secondary hyperparathyroidism.

Preparation

Cinacalcet hydrochloride (11 g, 0.028 mol) in toluene (150 mL) was added to potassium carbonate (7.74 g, 0.056 mol) followed by 1-(3-bromopropyl)-3-(trifluoromethyl)benzene (14.95 g, 0.056 mol) under stirring at 25-30 °C. The reaction was heated and stirred at 110-111 °C for 48 h. Upon completion of the reaction (by TLC), the reaction was cooled and quenched with water (100 mL). The organic layer was separated, washed with water (100 mL), and concentrated under reduced pressure to obtain a thick oil. The crude oil was then purified by column chromatography on silica gel by eluting with chloroform to afford Cinacalcet Impurity D as a thick transparent oil.

Cinacalcet Impurity D Preparation Products And Raw materials

Raw materials

Preparation Products

Cinacalcet Impurity D Suppliers

Global( 47)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
sgtlifesciences pvt ltd	+8617013299288	China	12382	58	Inquiry
China National Standard Pharmaceutical Corporation Limited	+8615391658522	China	11927	58	Inquiry
Shanghai YuZn Pharm. Technology Co.,Ltd.	15921286451; 15921286451	China	5063	58	Inquiry
Hubei Ruinuo Pharmaceutical Technology Co., Ltd	13165688766	China	5000	58	Inquiry
https://hanhongsci.com/	021-54306202 18917919676	China	29990	58	Inquiry
Molcoo Chemicals Inc.	18627923403 18627753421	China	9188	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
BOC Sciences	58
sgtlifesciences pvt ltd	58
China National Standard Pharmaceutical Corporation Limited	58
Shanghai YuZn Pharm. Technology Co.,Ltd.	58
Hubei Ruinuo Pharmaceutical Technology Co., Ltd	58
https://hanhongsci.com/	58
Molcoo Chemicals Inc.	58

1271930-15-4(Cinacalcet Impurity D)Related Search:

N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanaMide (αR)-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl)propyl]-1-napthaleneMethanaMine-N-oxide 1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-, hydrochloride (1:1), (αR)- 1-(7,8-dihydronaphthalen-1-yl)ethan-1-amine hydrochloride Cinacalcene Impurity I

Cinacalcet impurity C Cinacalcet Impurity 22 N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide Cinacalcet Impurity 21 (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine

Cinacalcet IMpurity 6 Cinacalcet IMpurity 3 (E)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)acrylamide Cinacalcet IMpurity 9 (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(M-tolyl)propan-1-aMine

N-(1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide 1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethan-1-amine hydrochloride Cinacalcet Impurity H

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cinacalcet iMpurity 8 1-NaphthaleneMethanaMine, α-Methyl-N,N-bis[3-[3-(trifluoroMethyl)phenyl]propyl]-, (αR)- (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propan-1-amine N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]-N-[3-[3-(trifluoromethyl)phenyl]propyl]propan-1-amine Cinacalcet Impurity D HCL Cinacalcet USP RC B Cinacalcet Impurity 5(Cinacalcet USP RC B) "(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl) Cinacalcet USP Related Compound B Cinacalcet impurity 20/(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propan-1-amine hydrochloride [(1R)-1-(naphthalen-1-yl)ethyl]bis({3-[3-(trifluoromethyl)phenyl]propyl})amine (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(2-(trifluoromethyl)phenyl)propan-1-amine hydrochloride (R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine, hydrogen chloride Cinacalcet Hydrochloride iMpuritX Cinacalcet Related Compund B (Cinacalcet Impurity D) Cinacalcet Impurity DQ: What is Cinacalcet Impurity D Q: What is the CAS Number of Cinacalcet Impurity D Q: What is the storage condition of Cinacalcet Impurity D Q: What are the applications of Cinacalcet Impurity D Cinacalcet tertiary amine CicalcetImpurity1HCl CicalcetImpurityDHCl 1-Naphthalenemethanamine, α-methyl-N,N-bis[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)- Cinacalcet Impurity D 1271930-15-4 C32H31F6N