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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

CAS No.: 394-32-1

Chemical Name:: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

Synonyms: 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5’-fluoro-2’-hydroxy-acetophenon;5'-Fluoro-2'-hydroxyacetophenone

CBNumber:: CB6267638

Molecular Formula:: C8H7FO2

Molecular Weight:: 154.14

MOL File:: 394-32-1.mol

MSDS File:: SDS

Modify Date:: 2025/1/27 9:38:02

Request For Quotation

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Properties

Melting point	56-58 °C(lit.)
Boiling point	65-66 °C8 mm Hg(lit.)
Density	1.1850 (estimate)
Flash point	65-66°C/8mm
storage temp.	Inert atmosphere,Room Temperature
pka	10.17±0.18(Predicted)
form	powder to crystal
color	White to Gray to Brown
Water Solubility	Soluble 0.68 G/L
BRN	2359087
CAS DataBase Reference	394-32-1(CAS DataBase Reference)
NIST Chemistry Reference	5-Fluoro-2-hydroxyacetophenone(394-32-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-37/39-36/37/39

WGK Germany

RTECS

AM8502300

HazardClass

IRRITANT

HS Code

29147000

NFPA 704

	1
2		0

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	247170	5′-Fluoro-2′-hydroxyacetophenone 98%	394-32-1	1G	₹1558.8	2022-06-14	Buy
Sigma-Aldrich(India)	247170	5′-Fluoro-2′-hydroxyacetophenone 98%	394-32-1	5G	₹6863.05	2022-06-14	Buy
TCI Chemicals (India)	F0318	5'-Fluoro-2'-hydroxyacetophenone min. 98.0 %	394-32-1	5G	₹6400	2022-05-26	Buy
TCI Chemicals (India)	F0318	5'-Fluoro-2'-hydroxyacetophenone min. 98.0 %	394-32-1	25G	₹7200	2022-05-26	Buy
ALFA India	ALF-A15614-14	5'-Fluoro-2'-hydroxyacetophenone, 98%	394-32-1	25g	₹15993	2022-05-26	Buy

Product number	Packaging	Price	Buy
247170	1G	₹1558.8	Buy
247170	5G	₹6863.05	Buy
F0318	5G	₹6400	Buy
F0318	25G	₹7200	Buy
ALF-A15614-14	25g	₹15993	Buy

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Uses,Production

Chemical Properties

light yellow to beige-brown crystals

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
3-hydroxy and 3-methoxyflavones
3-hydroxy and 3-methoxy 2-styrylchromones

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone 6-FLUOROCHROMONE 1-(2-ethoxy-5-fluorophenyl)ethan-1-one 2-(2-Aanilino-4-thiazolyl)-4-fluorophenol 1-(2-Hydroxy-5-fluorophenyl)ethanol

6-FLUOROCHROMONE-3-CARBOXYLIC ACID 97

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Suppliers

Global( 393)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4535	58	Inquiry
chromsynth pvt ltd	+919704220374	Hyderabad, India	244	58	Inquiry
Biosyn Research Chemicals	+91-91-9346022300 +91-9346022300	Telangana, India	465	58	Inquiry
Hyderabad	+91-9676447615 +91-9676447615	Telangana, India	192	58	Inquiry
SVH BIOSCIENCES	+91-6303499280 +91-6303499280	Hyderabad, India	478	58	Inquiry
chakrachem Lifesciences	+91 9902744663	Hyderabad, India	451	58	Inquiry
Dynarx Technology India Limited	+91-9960099480 +91-9960099480	Bangalore, India	71	58	Inquiry
Dr R R Organics	+91-9666306440 +91-9666306440	Telangana, India	267	58	Inquiry
BASR Fine Chemicals Pvt. Ltd.	+91-9848230391 +91-9848230391	Telangana, India	908	58	Inquiry
VCS Chem Tech Pvt Ltd	+91-8008851342 +91-8008851342	Telangana, India	66	58	Inquiry

Supplier	Advantage
GLR Innovations	58
chromsynth pvt ltd	58
Biosyn Research Chemicals	58
Hyderabad	58
SVH BIOSCIENCES	58
chakrachem Lifesciences	58
Dynarx Technology India Limited	58
Dr R R Organics	58
BASR Fine Chemicals Pvt. Ltd.	58
VCS Chem Tech Pvt Ltd	58

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Spectrum

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)MS 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)¹HNMR 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)¹³CNMR 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)IR1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)IR2 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)Raman

394-32-1(1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone)Related Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 6-Fluoro-4-chromanone 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-6'-HYDROXYACETOPHENONE

1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 4'-Fluoro-2'-hydroxyacetophenone 1-(2-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 2'-Hydroxyacetophenone 4-Fluorophenol

6-FLUORO-2-METHYL-4-CHROMANONE 6-FLUORO-3-FORMYLCHROMONE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE

(E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER

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2-Acetyl-4-fluorophenol 1-(5-FLUORO-2-HYDROXY-P 5-Fluoro-2-hydroxyphenyl(methyl) ketone 5'-Fluoro-2'-hydroxyacetophenone,97% 5’-fluoro-2’-hydroxy-acetophenon Ethanone, 1-(5-fluoro-2-hydroxyphenyl)- 2-HYDROXY-5-FLUOROACETOPHENONE 1-(5-FLUORO-2-HYDROXY-PHENYL)ETHANONE 1-(5-FLUORO-2-HYDROXYPHENYL)-1-ETHANONE 5'-Fluoro-2'-Hydroxyacetophenone 1-(5-Fluoro-2-Hydroxyphenyl)ethan-1-one 2-Hydroxy-5-Fluoroacetophenone99% 5-Fluoro-2-hydroxyacetophenone,98% 5'-Fluoro-2'-hydroxyacetopheno 2-Acety-4-fluorophenol 5'-fluoro-2'-hydroxyacetophenone,1-(5-fluoro-2-hydroxy)ethanone 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4-fluorophenol JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97% 5'-Fluoro-2'-hydroxyacetophenone> 2-hydroxy-5-fluorophenone 5’-Fluoro-2’-hydroxyacetophenone,1-(5-Fluoro-2-hydroxyphenyl)ethanone,5‘-Fluoro-2‘-hydroxyacetophenone,5'-Fluoro-2'-hydroxyacetophenone TIANFUCHEM 394-32-1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 5-FLUORO-2-HYDROXYACETOPHENONE 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE 1-(5-Fluor-2-hydroxyphenyl)ethan-1-on 1-(5-fluro-2-hydroxyphenyl)ethanone 5'-Fluoro-2'-hydroxyacetophenone 5′-Fluoro-2′-hydroxyacetophenone, CAS 394-32-1 394-32-1 Building Blocks Carbonyl Compounds C7 to C8 KETONE Ketones Organic Building Blocks Aryl Fluorinated Building Blocks Building Blocks C7 to C8 C7-C8 Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Acetophenone series Adehydes, Acetals & Ketones Fluorine Compounds Phenols C7 to C8 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) ketone (intermediate of nebivolol) Benzenes Alcohols and Derivatives Carbonyl Compounds 1