Methotrexate γ-Methyl Ester

Methotrexate γ-Methyl Ester Structure
CAS No.
67022-39-3
Chemical Name:
Methotrexate γ-Methyl Ester
Synonyms
Methotrexate Impurity H;Methotrexate EP Impurity H;Methotrexate γ-Methyl Ester;Methotrexate Impurity 8(EP-H);Methotrexate-5-monomethyl ester;Methotrexate gamma-Methyl Ester;Methotrexate USP Related Compound H;Methotrexate-Methyl Ester (TEA salt);Methotrexate γ-Methyl Ester (Impurity H);Methotrexate Impurity 8(Methotrexate EP Impurity H)
CBNumber:
CB62695972
Molecular Formula:
C21H24N8O5
Molecular Weight:
468.47
MOL File:
67022-39-3.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:43:35

Methotrexate γ-Methyl Ester Properties

Melting point 170-174 °C
Density 1.459±0.06 g/cm3(Predicted)
solubility Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Heated)
pka 3.43±0.10(Predicted)
form Solid
color Light Yellow to Orange
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Methotrexate γ-Methyl Ester Chemical Properties,Uses,Production

Uses

Methotrexate γ-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.

Methotrexate γ-Methyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Methotrexate EP Impurity H Methotrexate Impurity 8(EP-H) Methotrexate EP Impurity H (Methotrexate-5-Monomethyl Ester) Methotrexate-5-monomethyl ester Methotrexate EP Impurity H(Amethopterin EP Impurity H) Methotrexate γ-Methyl Ester (Impurity H) (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid Methotrexate Impurity H L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 5-methyl ester Methotrexate Impurity 8(Methotrexate EP Impurity H) (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-methoxy-5-oxopentanoic acid Methotrexate-Methyl Ester (TEA salt) Methotrexate EP Impurity H (Methotrexate 5-Methyl Ester) Methotrexate USP Related Compound H Methotrexate gamma-Methyl Ester Methotrexate γ-Methyl Ester 67022-39-3 Aromatics, Chiral Reagents, Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals