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Methotrexate α-Methyl Ester

Methotrexate α-Methyl Ester Structure
CAS No.
66147-29-3
Chemical Name:
Methotrexate α-Methyl Ester
Synonyms
Methotrexate Impurity I;Methotrexate EP Impurity I;JYFDQHNTJJOKAS-AWEZNQCLSA-N;Methotrexate-a-Methyl Ester;Methotrexate Impurity 9(EP-I);Methotrexate-1-monomethyl ester;Methotrexate alpha-methyl ester;Methotrexate related compound I;Methotrexate α-Methyl Ester (Impurity I);Methotrexate α-Methyl Ester (Impurity I)
CBNumber:
CB32695971
Molecular Formula:
C21H24N8O5
Molecular Weight:
468.47
MOL File:
66147-29-3.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:43:35

Methotrexate α-Methyl Ester Properties

solubility Aqueous Base (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form Solid
color Light Yellow to Dark Orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Methotrexate α-Methyl Ester Chemical Properties,Uses,Production

Uses

Methotrexate α-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.

Methotrexate α-Methyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Methotrexate EP Impurity I(Amethopterin EP Impurity I) (4S)-4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid Methotrexate EP Impurity I/Methotrexate 1-Methyl Ester/Methotrexate α-Methyl Ester/(4S)-4-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid Methotrexate EP Impurity I (Methotrexate-1-Monomethyl Ester) Methotrexate-1-monomethyl ester Methotrexate Impurity I L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-methyl ester (S)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-methoxy-5-oxopentanoic acid Methotrexate Impurity 9(Methotrexate EP Impurity I) Methotrexate α-Methyl Ester,(S)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-methoxy-5-oxopentanoic acid JYFDQHNTJJOKAS-AWEZNQCLSA-N Methotrexate EP Impurity I Methotrexate Impurity 9(EP-I) Methotrexate α-Methyl Ester (Impurity I) Methotrexate-a-Methyl Ester Methotrexate α-Methyl Ester (Impurity I) Methotrexate alpha-methyl ester Methotrexate related compound I 66147-29-3 Aromatics, Chiral Reagents, Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals