CYCLOPENTOLATE HYDROCHLORIDE
- CAS No.
- 5870-29-1
- Chemical Name:
- CYCLOPENTOLATE HYDROCHLORIDE
- Synonyms
- Alnide;cyclogyl;Zyklolat;Mydplegic;5-Hydroxy-1;Ak-Pentolate;Cyclopentolate HCl USP;Cyclogyl hydrochloride;LABOTEST-BB LT00244824;CYCLOPENTOLATE HYDROCHLORIDE
- CBNumber:
- CB6287038
- Molecular Formula:
- C17H26ClNO3
- Molecular Weight:
- 327.85
- MOL File:
- 5870-29-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:13
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GY2450000 | |||||||||
| HS Code | 2922190900 | |||||||||
| NFPA 704 |
|
CYCLOPENTOLATE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively). Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.
Chemical Properties
White Solid
Uses
Mydriatic;Cholinergic receptor antagonist
General Description
Cyclopentolatehydrochloride, 2-dimethylaminoethyl 1-hydroxy- -phenylcyclopentaneacetatehydrochloride (Cyclogyl), is a crystalline,white, odorless solid that is very soluble in water,easily soluble in alcohol, and only slightly soluble in ether.A 1% solution has a pH of 5.0 to 5.4.
Cyclopentolate hydrochloride has one half of the antispasmodicactivity of atropine and is nonirritating when instilledrepeatedly into the eye. If not neutralized after the refractionstudies, its effect dissipates within 24 hours. Neutralizationwith a few drops of pilocarpine nitrate solution, 1% to 2%,often results in complete recovery in 6 hours. It is supplied asa ready-made ophthalmic solution in concentrations of either0.5% or 2%.
Clinical Use
Cyclopentolate Hydrochloride is used only for its effects on the eye, where it acts asa parasympatholytic. When placed in the eye, it quickly producescycloplegia and mydriasis. Its primary field of usefulnessis in refraction studies. Cyclopentolate hydrochloridecan be used, however, as a mydriatic in the management ofiritis, iridocyclitis, keratitis, and choroiditis. Although itdoes not seem to affect intraocular tension significantly, it isbest to be very cautious with patients with high intraocularpressure and with elderly patients with possible unrecognizedglaucomatous changes.
CYCLOPENTOLATE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNA HEALTHCARE PVT LTD | +91-8652842416 +91-8652842416 | Mumbai, India | 88 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Sanvin Group of Companies (Pioneer Agro Industries) | +91-2261066638 +91-2261066600 | Maharashtra, India | 27 | 58 | Inquiry |
| Ar Ex Laboratories Pvt Ltd | 91-22-24454109 | Maharashtra, India | 18 | 58 | Inquiry |
| Bioxera Pharma Pvt. Ltd. | +91-2261842739 +91-2266862739 | Maharashtra, India | 20 | 58 | Inquiry |
| Vivimed Labs Ltd | +914066086608 | Telangana, India | 61 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Om Pharmaceutical Industries | 08066085835Ext 129 | Mumbai, India | 24 | 58 | Inquiry |
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