DBCO-Acid
- CAS No.
- 1353016-70-2
- Chemical Name:
- DBCO-Acid
- Synonyms
- Dibenzocyclooctyne-acid;DBCO-Acid;DBCO-COOH;DBCO acid 1;DBCO-C4-COOH;CAS_1353016-70-2;DBCO-(CH2)2-COOH;DBCO Acid (CCT-1117);Azadibenzocyclooctyne acid;Diphenylcyclooctyne carboxylic acid
- CBNumber:
- CB62985653
- Molecular Formula:
- C19H15NO3
- Molecular Weight:
- 305.33
- MOL File:
- 1353016-70-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 118-125 °C |
|---|---|
| Boiling point | 622.0±55.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in dimethyl sulfoxide and dimethyl formamide. |
| pka | 4.47±0.17(Predicted) |
| form | Solid |
| color | Off-white to Gray |
| InChI | InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23) |
| InChIKey | NDLOVDOICXITOK-UHFFFAOYSA-N |
| SMILES | O=C(C([H])([H])C([H])([H])C(=O)O[H])N1C2=C([H])C([H])=C([H])C([H])=C2C#CC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
| HS Code | 29339900 |
DBCO-Acid Chemical Properties,Uses,Production
Uses
DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.
Application
DBCO-acid (11,12-Didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanoic acid) is a cleavable antibody-drug conjugate (ADC) linker used in the synthesis of ADC linkers DBCO-NHS ester (HY-115524 and HY-115545) and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid is also a click chemistry reagent that contains a DBCO group in its structure and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.
General Description
Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
DBCO-Acid Preparation Products And Raw materials
DBCO-Acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ChemExpress | +86-021-58950125 +86-021-58950125; | China | 782 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19841 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10406 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 8497 | 58 | Inquiry |
| Accela ChemBio Inc. | +1-858-6993322 | United States | 20014 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 12226 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32239 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30230 | 58 | Inquiry |