UNC3230
![UNC3230 Structure](CAS/20180713/GIF/1031602-63-7.gif)
- CAS No.
- 1031602-63-7
- Chemical Name:
- UNC3230
- Synonyms
- UNC3230;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
- CBNumber:
- CB63067589
- Molecular Formula:
- C17H20N4O2S
- Molecular Weight:
- 344.43
- MOL File:
- 1031602-63-7.mol
- Modify Date:
- 2024/7/2 8:55:13
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
UNC3230 Chemical Properties,Uses,Production
Description
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.
Uses
UNC 3230 is a potent inhibitor of PIP5K1C.
UNC3230 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2971 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
Tocris Bioscience | +44 (0) 117 916 3333 | United Kingdom | 5729 | 77 | Inquiry |
United States Biological | 1-800-520-3011 | United States | 6106 | 58 | Inquiry |
ApexBio Technology | + 1-832-696-8203 | United States | 6254 | 58 | Inquiry |
Supplier | Advantage |
---|---|
ATK CHEMICAL COMPANY LIMITED | 60 |
BOC Sciences | 58 |
TargetMol Chemicals Inc. | 58 |
InvivoChem | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | 58 |
Aladdin Scientific | 58 |
Amadis Chemical Company Limited | 58 |
Tocris Bioscience | 77 |
United States Biological | 58 |
ApexBio Technology | 58 |