ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >UNC2881
UNC2881
![UNC2881 Structure](CAS/20150408/GIF/1493764-08-1.gif)
- CAS No.
- 1493764-08-1
- Chemical Name:
- UNC2881
- Synonyms
- 110849;UNC2881;CS-1177;UNC2881 USP/EP/BP;UNC 2881; UNC-2881;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide;2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
- CBNumber:
- CB52715677
- Molecular Formula:
- C25H33N7O2
- Molecular Weight:
- 463.58
- MOL File:
- 1493764-08-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:11
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
NFPA 704 |
|
UNC2881 Chemical Properties,Uses,Production
Description
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.
Uses
UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.
UNC2881 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 67)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
Supplier | Advantage |
---|---|
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
ATK CHEMICAL COMPANY LIMITED | 60 |
TargetMol Chemicals Inc. | 58 |
Career Henan Chemica Co | 58 |
Dideu Industries Group Limited | 58 |
InvivoChem | 58 |
LEAPCHEM CO., LTD. | 58 |
Aladdin Scientific | 58 |
Amadis Chemical Company Limited | 58 |
1493764-08-1(UNC2881)Related Search:
2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
UNC2881
N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide
N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881
N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine
110849
UNC 2881; UNC-2881
CS-1177
5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
UNC2881 USP/EP/BP
N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide
UNC 2881,Mer,phosphorylation,inhibit,UNC-2881,orally active,UNC2881,Tyro3,pathologic thrombosis,Axl,Inhibitor,platelet aggregation,TAM Receptor
1493764-08-1
Inhibitors