CYTOCHALASIN B
- CAS No.
- 14930-96-2
- Chemical Name:
- CYTOCHALASIN B
- Synonyms
- cytochalasin;PHOMIN;-23-one;CYTOCHALACINB;CYTOCHALICINB;CYTOCHALASIN B;CYTOCHALASIN B(RG);Cytochalasin B (Phomin);CYTOCHALASIN B USP/EP/BP;(7s,13e,16r,20r,21e)-0-phenyl
- CBNumber:
- CB6323824
- Molecular Formula:
- C29H37NO5
- Molecular Weight:
- 479.61
- MOL File:
- 14930-96-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:08:57
| Melting point | 218-223 °C |
|---|---|
| Boiling point | 577.96°C (rough estimate) |
| Density | 1.1490 (rough estimate) |
| refractive index | 1.6290 (estimate) |
| Flash point | 85℃ |
| storage temp. | -20°C |
| solubility | ethanol: 20 mg/mL |
| form | powder |
| pka | 13.60±0.70(Predicted) |
| color | white |
| Merck | 13,2819 |
| BRN | 1096207 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | UXVDBQLLXVKPRS-UZBFCAAUSA-N |
| LogP | 3.370 |
| EPA Substance Registry System | Cytochalasin B (14930-96-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H361 | |||||||||
| Precautionary statements | P201-P202-P260-P280-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+,T | |||||||||
| Risk Statements | 26/27/28-63-23/24/25 | |||||||||
| Safety Statements | 28-36/37-45 | |||||||||
| RIDADR | UN 1544 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RO0205000 | |||||||||
| F | 10 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29349990 | |||||||||
| Hazardous Substances Data | 14930-96-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 30mg/kg | |||||||||
| NFPA 704 |
|
CYTOCHALASIN B price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C6762 | Cytochalasin B from Drechslera dematioidea ≥98% (HPLC), powder | 14930-96-2 | 1MG | ₹9233.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6762 | Cytochalasin B from Drechslera dematioidea ≥98% (HPLC), powder | 14930-96-2 | 5MG | ₹38071.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6762 | Cytochalasin B from Drechslera dematioidea ≥98% (HPLC), powder | 14930-96-2 | 10MG | ₹55131.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6762 | Cytochalasin B from Drechslera dematioidea ≥98% (HPLC), powder | 14930-96-2 | 25MG | ₹103573.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6762 | Cytochalasin B from Drechslera dematioidea ≥98% (HPLC), powder | 14930-96-2 | 50MG | ₹178168.68 | 2022-06-14 | Buy |
CYTOCHALASIN B Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder
Uses
Cytochalasin B is one of the most extensively studied members of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin B exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of this class display diverse selectivity. However, lack of comparative co-metabolite analysis has restricted a more complete understanding of their individual selectivity.
Definition
ChEBI: An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.
General Description
Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:
- Disruption of actin filaments and of interaction of actin filaments in solution
- Inhibition of actin polymerization
- Inhibition of subunit association and dissociation
Purification Methods
Purify it by MeOH extraction, reverse phase C18 silica gel batch extraction by selective elution with 1:1 v/v hexane/tetrahydrofuran, crystallisation, subjected to TLC and recrystallisation [Lipski et al. Anal Biochem 161 332 1987]. It is soluble in EtOH (3.6%), Me2CO (1%), Me2SO (37%) and Me2NCHO (49%) at 24o, and can be crystallised from the first two solvents. It interferes with cellular movement [Korm Physiol Reviews 62 672 1982].
CYTOCHALASIN B Preparation Products And Raw materials
Global( 185)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29880 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39894 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49374 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10319 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34563 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23541 | 58 | Inquiry |
14930-96-2(CYTOCHALASIN B)Related Search:
CYTOCHALASIN E
CYTOCHALASIN A
CYTOCHALASIN C
CYTOCHALASIN D
CYTOCHALASIN B, DIHYDRO,CYTOCHALASIN B, DIHYDRO
ETHYL TRANS-2-DECENOATE
ISO-AMYL-CROTONATE
cis-Octahydro-isoindole
(S)-(+)-1-Cyclohexylethylamine
2-METHOXY-2-METHYL-PROPYLAMINE
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1of4
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CytochalasinB from Drechslera dematioidea,Phomin
Cytochalasin B, froM Drechslera deMatoidea
Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
Cytochalasin B from Helminthosporium dematioideum
ec[2,3-d]isoindole-2,18(5h)-dione
(E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE
CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM
CYTOCHALASIN B
,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e,e)
,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2h-oxacyclotetrad
-23-one
24-oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-1
2h-oxacyclotetradec(2,3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13
3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-2h-oxacyclotetradec(
7,20-dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-[14]cytochalas-6(12),13,21-trien
7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
Cytochalasin beta,helminthosporium dematioideum
cytochalasin b from drechslera dematioidea
CYTOCHALASIN B(RG)
CYTOCHALACINB
CYTOCHALICINB
CYTOCHALASIN B FROM HELMINTHOSPORIUM DEMATIODEUM
(7S,13E,16R,20R,21E)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione
(7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
(7s,13e,16r,20r,21e)-0-phenyl
(e,e)-(5s,9r,12as,13s,15s,15as,16s,18as)-16-benzyl-6,7,8,9,10,12a,13,14,15,15a
,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e)-(
9r,12as,13s,15s,15as,16as,18as)-5
9r,12as,13s,15s,15as,16s,18as)--(5
CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA
CYTOCHALASIN B SYNTHETIC >97%
CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 95.0% (HPLC)
Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem
(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
Cytochalasin B (Phomin)
Cytochalasin B (Synonyms: Phomin)
Cytochalasin B, 98%, from Drechslera dematoidea
2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione,6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-,(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
CYTOCHALASIN B USP/EP/BP
16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-2H,5H,6H,7H,8H,9H,10H,12aH,13H,14H,15H,15aH,16H,17H,18H-oxacyclotetradeca[3,2-e]isoindole-2,18-dione
cytochalasin
PHOMIN
Cytochalasin B, actin polymerization inhibitor
14930-96-2
C29H37NO5
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