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CYTOCHALASIN A

CYTOCHALASIN A Structure
CAS No.
14110-64-6
Chemical Name:
CYTOCHALASIN A
Synonyms
Dehydrophomin;CYTOCHALASIN A;CYTOCHALASIN A(RG);5,5-Didehydrophomin;Cytochalasin dreschslera dematioidea;CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA;CytochalasinA from Drechslera dematioidea;cytochalasin a from helminthosporium dematioideum;Cytochalasin A 5-Dehydrophomin Dehydrophomin;CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 99.0% (TLC)
CBNumber:
CB6735221
Molecular Formula:
C29H35NO5
Molecular Weight:
477.59
MOL File:
14110-64-6.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:01:59

CYTOCHALASIN A Properties

Melting point 190-191 °C
Boiling point 725.1±60.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility ethanol: 20 mg/mL, clear, colorless
pka 13.54±0.70(Predicted)
form Powder
color White
Water Solubility Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
Sensitive Light Sensitive
BRN 949521
LogP 1.849 (est)
EPA Substance Registry System Cytochalasin A (14110-64-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300+H310+H330-H361
Precautionary statements  P201-P202-P260-P280-P302+P352+P310-P304+P340+P310
Hazard Codes  T+,T
Risk Statements  26/27/28-63
Safety Statements  28-36/37-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
10
HazardClass  6.1(a)
PackingGroup  I
HS Code  29349990
NFPA 704
0
4 0

CYTOCHALASIN A price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C6637 Cytochalasin A from Drechslera dematioidea 14110-64-6 1MG ₹14267.35 2022-06-14 Buy
ottokemi C 3040 Cytochalasin A, from drechslera dematioidea 99% 14110-64-6 1mg ₹13005 2022-05-26 Buy
ottokemi C 3040 Cytochalasin A, from drechslera dematioidea 99% 14110-64-6 10mg ₹110079 2022-05-26 Buy
Product number Packaging Price Buy
C6637 1MG ₹14267.35 Buy
C 3040 1mg ₹13005 Buy
C 3040 10mg ₹110079 Buy

CYTOCHALASIN A Chemical Properties,Uses,Production

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.

Chemical Properties

white powder

Uses

Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin A exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of the class display diverse selectivity. Specifically, cytochalasin A is one of the few cytochalasins exhibiting activity against HIV-1 protease.

CYTOCHALASIN A Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 97)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
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ABCR GmbH & CO. KG 49 721 95061 0 Germany 6846 75 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 China 8141 58 Inquiry
Shanghai kadel chemical technology co., LTD 021-4007787-550 400-7787-550 China 10599 58 Inquiry
Nantong Feiyu Biological Technology CO.,LTD 0513-68819626; 13813788405 China 4821 58 Inquiry
(7S,13E,16R,21E)-7-Hydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,20,23-trione 5,5-Didehydrophomin Dehydrophomin Cytochalasin dreschslera dematioidea Cytochalasin A 5-Dehydrophomin Dehydrophomin 7(S)-hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,20,23-trione 2H-Oxacyclotetradecino2,3-disoindole-2,5,18-trione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)- CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 99.0% (TLC) CYTOCHALASIN A cytochalasin a from helminthosporium dematioideum CYTOCHALASIN A(RG) CytochalasinA from Drechslera dematioidea 14110-64-6 C29H35NO5 Other Cytoskeleton and Extracellular Matrix Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Type Cell Biology Cell Signaling and Neuroscience Biochemicals and Reagents BioChemical Actin Inhibitors and Probes Actin Inhibitors and ProbesCell Signaling and Neuroscience Cell Signaling and Neuroscience antibiotic Cytoskeleton and Extracellular Matrix Mold Toxins and Venoms