1,3-Dimethylamylamine
- CAS No.
- 105-41-9
- Chemical Name:
- 1,3-Dimethylamylamine
- Synonyms
- 1,3-Dimethylamylamine;Methylhexaneamine;DiMethylaMylaMine;Methylhexanamine;4-Methylhexan-2-amine;4-Methyl-2-hexanamine;2-Hexanamine, 4-methyl-;Forthan;Fouramin;Forthane
- CBNumber:
- CB8211488
- Molecular Formula:
- C7H17N
- Molecular Weight:
- 115.22
- MOL File:
- 105-41-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/24 18:18:52
| Melting point | -19°C (estimate) |
|---|---|
| Boiling point | bp760 130-135° |
| Density | 0.7620-0.7655 |
| refractive index | n20/D1.417-1.419 |
| Flash point | 43℃ |
| pka | pKa 10.54(H2O,t =24±1,I=0.002) (Uncertain) |
| InChI | InChI=1S/C7H17N/c1-4-6(2)5-7(3)8/h6-7H,4-5,8H2,1-3H3 |
| InChIKey | YAHRDLICUYEDAU-UHFFFAOYSA-N |
| SMILES | CC(N)CC(C)CC |
| CAS DataBase Reference | 105-41-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Hexanamine, 4-methyl-(105-41-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H226-H302-H314-H335 |
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 |
| Hazard Codes | C |
| Risk Statements | 10-22-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2734PSN1 3(8) / PGII |
| WGK Germany | 3 |
| RTECS | SC0800000 |
1,3-Dimethylamylamine Chemical Properties,Uses,Production
Description
1,3-dimethylamylamine or methylexaneamine (DMAA) is a synthetic pharmaceutical patented in the 1940s as a nasal decongestant which can be used as a recreational stimulant. Alleged to occur in nature，DMAA has become a widely used ingredient in sports food supplements, despite its status as a doping agent and concerns over its safety. The most popular brands containing DMAA include Jack3d? and OxyElite Pro?, both marketed by USP Labs and both detained by the FDA in July 2013 (however, some can still be found on Amazon and other online retail stores).
Chemical Properties
White or almost white powder
Uses
DMAA (1,3-dimethylamylamine) is an amphetamine derivative that has been widely used in sports supplements sold in the United States. Also known as methylhexanamine or geranium extract, DMAA is often touted as a "natural" stimulant, with many claimed functional uses including a body-building aid, an athletic performance enhancer, and a weight-loss aid. Although DMAA at one time was approved as a drug for nasal decongestion, no medical use of DMAA is recognized today. FDA is not aware of any reliable science indicating that DMAA exists naturally in plants.
Application
1,3-Dimethylamylamine (1,3-DMAA) is a neural stimulant with a structure similar to ephedrine and adrenaline that has been used as a pre-workout stimulant. It is useful in compositions, for example as dietary supplements, and for appetite suppression. Methylhexaneamine is a botanical ingredient in dietary supplements. Methylhexaneamine and caffeine has been combined in attempts to improve exercise performance and related variables.
Definition
Compared to the commonly available stimulant caffeine, DMAA has a longer t1/2, in this case 8.4 h vs. 5.4 hr for caffeine, as well as a shorter lag time of 0.14 h vs. 0.37 h for caffeine. Previous reports have indicated that DMAA is absorbed over 4–12 hours.
Pharmacokinetics
Oral Clearance (CL) values (CL/F; F represents oral bioavailability) were found to be relatively low (20±5.0 L/hr), whereas oral Volume of distribution (V/F) was relatively high (236±38.0 L). A 25 mg single oral dose resulted in a maximum plasma concentration (Cmax) of 76.5 ng/mL, which occurred approximately 4 hours post-ingestion. Cmaxvalues were approximately 15-30 times lower than those reported in case studies linking 1,3-Dimethylamylamine (DMAA) intake with severe adverse events, suggesting that the reported adverse events were associated with a DMAA intake much higher than the 25 mg dose in our study [9,10]. Additionally, the potential impact of drug-drug interactions should be considered when interpreting DMAA adverse event reports. Because DMAA PK data suggest that a significant fraction of an orally administered DMAA dose is metabolized, concomitant administration of common ingredients that are also metabolized (e.g., caffeine), may lead to exaggerated DMAA concentrations by inhibiting DMAA clearance.
Side effects
Taking 1,3-Dimethylamylamine (DMAA) can raise blood pressure and lead to cardiovascular problems ranging from shortness of breath and tightening in the chest to heart attack. It may also cause stroke, a condition called lactic acidosis, heart attack, liver injury, and death.
1,3-Dimethylamylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | China | 887 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5959 | 58 | Inquiry |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | China | 1000 | 58 | Inquiry |
| zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | China | 260 | 58 | Inquiry |
| Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 +86-13082019107 | China | 225 | 58 | Inquiry |
| Sigma Audley | +86-18336680971 +86-18126314766 | China | 497 | 58 | Inquiry |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | China | 989 | 58 | Inquiry |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | China | 2901 | 58 | Inquiry |
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