EMEDASTINE FUMARATE
- CAS No.
- 87233-62-3
- Chemical Name:
- EMEDASTINE FUMARATE
- Synonyms
- Emadine;1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazoledifumarate;Daren;kb2413;Remicut;kb-2413;kg-2413;AL 3432A;Rapimine;ly188695
- CBNumber:
- CB6714475
- Molecular Formula:
- C25H34N4O9
- Molecular Weight:
- 534.56
- MOL File:
- 87233-62-3.mol
- Modify Date:
- 2024/4/15 15:30:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| RTECS | DD8870000 | |||||||||
| HS Code | 2933992600 | |||||||||
| Toxicity | LD50 orally in guinea pigs: 744 mg/kg (Fukuda) | |||||||||
| NFPA 704 |
|
EMEDASTINE FUMARATE Chemical Properties,Uses,Production
Description
Emedastine difumarate, a potent H1-receptor antagonist, was launched in Japan for the treatment of allergic rhinitis and urticaria. Emedastine exerts its antiallergic effect via inhibition of substance P-induced histamine release. It has been demonstrated both in vitro and in vivo that this effect is mediated by the inhibition of Ca2+release from extracellular stores and of Ca2+ influx into mast cells. In a clinical trial with bronchial asthma, emedastine improved asthmatic symptoms in 55.3% of patients.
Chemical Properties
White or yellowish powder
Uses
Antihistaminic, H1-receptor; asthma prophylactic; anti-allergic.
Definition
ChEBI: The fumaric acid salt of emedastine containing two molecules of fumaric acid for each molecule of emedastine. A relatively selective histamine H1 antagonist, it is used for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.
Hazard
A poison by ingestion.
EMEDASTINE FUMARATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20296 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11506 | 58 | Inquiry |