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ACPT-I

ACPT-I Structure
CAS No.
194918-76-8
Chemical Name:
ACPT-I
Synonyms
ACPT-I;ACPT I,ACPTI;(1S,3R,4S)-1-AMINOCYCLOPENTANE-1,3,4-TRICARBOXYLIC ACID;4-AMINO-1BETA,2BETA,4BETA-CYCLOPENTANETRICARBOXYLIC ACID;1,2,4-Cyclopentanetricarboxylic acid, 4-amino-, (1α,2α,4β)-
CBNumber:
CB6768791
Molecular Formula:
C8H11NO6
Molecular Weight:
217.18
MOL File:
194918-76-8.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

ACPT-I Properties

Boiling point 440.4±45.0 °C(Predicted)
Density 1.651±0.06 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
form Powder
pka 1.85±0.60(Predicted)

ACPT-I Chemical Properties,Uses,Production

Description

ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.

Biological Activity

Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.

ACPT-I Preparation Products And Raw materials

Raw materials

1,3-Diazaspiro[4.4]nonane-7,8-dicarboxylic acid, 2,4-dioxo-

Preparation Products

ACPT-I Suppliers

Global( 25)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4551 58 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 14059 65 Inquiry
Nacalai Tesque, Inc. 81 75 251 1723 Japan 6048 75 Inquiry
MOLEKULA Ltd. +44 (0) 1747 831066 United Kingdom 6152 66 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
BOC Sciences 65
Nacalai Tesque, Inc. 75
MOLEKULA Ltd. 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Tocris Bioscience 77
ApexBio Technology 58

194918-76-8(ACPT-I)Related Search:

H-ALPHA-ME-D-LEU-OH (1S,3R)-3-Aminocyclopentanecarboxylic acid L-2-Aminoadipic acid ACPT-I CIS-CYCLOPENTANE-1,2-DICARBOXYLIC ACID
(+/-)-1-AMINOCYCLOPENTANE-CIS-1,3-DICARBOXYLIC ACID DL-2-AMINOADIPIC ACID (1S,3R)-ACPD DL-2-METHYLGLUTAMIC ACID (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID
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ACPT-I 4-AMINO-1BETA,2BETA,4BETA-CYCLOPENTANETRICARBOXYLIC ACID (1S,3R,4S)-1-AMINOCYCLOPENTANE-1,3,4-TRICARBOXYLIC ACID 1,2,4-Cyclopentanetricarboxylic acid, 4-amino-, (1α,2α,4β)- ACPT I,ACPTI 194918-76-8