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SSR 69071

SSR 69071 Structure
CAS No.
344930-95-6
Chemical Name:
SSR 69071
Synonyms
SSR 69071;2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-
CBNumber:
CB6838847
Molecular Formula:
C27H32N4O7S
Molecular Weight:
556.63
MOL File:
344930-95-6.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

SSR 69071 Properties

storage temp. Store at +4°C
solubility Soluble in DMSO
form solid
color Off-white

SSR 69071 Chemical Properties,Uses,Production

Description

SSR 69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury.

Uses

SSR 69071 is a novel and orally active elastase inhibitor.

Biological Activity

Orally active, high affinity and potent inhibitor of human leukocyte elastase (HLE) (IC 50 = 3.9 nM). Displays species-selectivity (K i values are 0.017, 1.70, 3.01, 58 and > 100 nM? for human, mouse, rat, rabbit and porcine elastase respectively). In vivo, inhibits HLE-induced lung hemorrhage in mice (ID 50 = 2.8 mg/kg) and reduces infarct size in an acute model of coronary ischemia-reperfusion injury.

SSR 69071 Preparation Products And Raw materials

Raw materials

Preparation Products

SSR 69071 Suppliers

Global( 23)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
Axon Medchem LLC 703 - 9861 United States 763 58 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Boao Pike 010-57798038 15652371397 CHINA 6629 58 Inquiry
Beijing Chief-East Tech Co.,Ltd (Qwbio) 010-82743161 China 6912 50 Inquiry
Shanghai Weiwei Biological Technology Co., Ltd. 021-55669583 18616258598 CHINA 4398 58 Inquiry
Beijing Taize Ruida Technology Co., Ltd. 400-800-8151 13651185998 CHINA 6536 58 Inquiry
Supplier Advantage
Aladdin Scientific 58
Service Chemical Inc. 71
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Tocris Bioscience 77
Axon Medchem LLC 58
ApexBio Technology 58
Boao Pike 58
Beijing Chief-East Tech Co.,Ltd (Qwbio) 50
Shanghai Weiwei Biological Technology Co., Ltd. 58
Beijing Taize Ruida Technology Co., Ltd. 58

344930-95-6(SSR 69071)Related Search:

SSR 69071 N-HYDROXYMETHYLSACCHARIN 1,2-BENZISOTHIAZOL-3(2H)-ONE, 6-METHOXY, 1,1-DIOXIDE
SSR 69071 2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]- 344930-95-6