ECOTHIOPATE IODIDE
- CAS No.
- 513-10-0
- Chemical Name:
- ECOTHIOPATE IODIDE
- Synonyms
- 217MI;Echodide;Ecostigmine;Ecothiopate;ECOTHIOPHATE;ECHOTHIOPHATE;PHOSPHOLINEIODIDE;ECOTHIOPATE IODIDE;Echothiopate iodide;EcostigMini jodiduM
- CBNumber:
- CB6839268
- Molecular Formula:
- C9H23INO3PS
- Molecular Weight:
- 383.227051
- MOL File:
- 513-10-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:09
| Melting point | 138° (Tammelin); mp 124-124.5° (Fitch) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble |
| form | A solid |
| Stability | Hygroscopic |
| EPA Substance Registry System | Ethanaminium, 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-, iodide (513-10-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311+H331-H400 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P273-P280-P301+P310-P321-P330-P302+P352-P304+P340-P311-P312-P361+P364-P391-P403+P233-P405-P501 | |||||||||
| RIDADR | 3249 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| NFPA 704 |
|
ECOTHIOPATE IODIDE Chemical Properties,Uses,Production
Uses
Cholinergic (ophthalmic).
Uses
Echothiophate is a phosphorylthiocholine with pharmacological action analogous to that of isofluorophate; however, spontaneous reduction of phosphorylated enzyme occurs faster after using isofluorophate. It is used in various forms of glaucoma.
Definition
ChEBI: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Clinical Use
Echothiophate iodide has found therapeutic application for the treatment of glaucoma and strabismus. Echothiophate is applied topically as a solution and is the only irreversible AChEI for the treatment of glaucoma. The decrease in intraocular pressure observed can last up to 4 weeks. Phosphoester AChEIs exhibit cataractogenic properties; thus, their use should be reserved for patients who are refractory to other forms of treatment (i.e., short-acting miotics, β-blockers, epinephrine, and possibly, carbonic anhydrase inhibitors). Because of its toxicity, echothiophate is not used for its systemic action. Selectivity of echothiophate for the AChE catalytic site was enhanced by incorporation in the molecule of a quaternary ammonium salt functional group two carbons removed from the phosphoryl group.
Synthesis
Echothiophate, S-(2-trimethylaminoethyl)-O,O-diethylthiophosphate (13.2.23), is made by reacting diethylchlorophosphoric acid with 2-dimethylaminoethylmercaptane, giving S-(2-dimethylaminoethyl)-O,O-diethylthiophosphate (13.2.22), which is alkylated by methyliodide, forming echothiophate (13.2.23) [51].
ECOTHIOPATE IODIDE Preparation Products And Raw materials
ECOTHIOPATE IODIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |
| BOC Sciences | 1-631-485-4226; 16314854226 | United States | 14059 | 65 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9282 | 58 | Inquiry |
| ChemPacific Corporation | 410 633 5771 | United States | 6902 | 51 | Inquiry |
| A.T.CHEMICAL | 0755-86655561 81899190 | China | 6594 | 51 | Inquiry |
| APAC Pharmaceutical, LLC | +1(410) 997 5552 | United States | 6332 | 38 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
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