Econazole
- CAS No.
- 27220-47-9
- Chemical Name:
- Econazole
- Synonyms
- ECONAZOLE;NSC 187789;ECONAZOLUM;(±)-Econazol;Econazole CRS;Econazole USP/EP/BP;Econazole Solution, 100ppm;Miconazole Nitrate EP Impurity B;Econazole (base and/or unspecified salts);Econazole(Miconazole nitrate EP impurity B)
- CBNumber:
- CB9447792
- Molecular Formula:
- C18H15Cl3N2O
- Molecular Weight:
- 381.68
- MOL File:
- 27220-47-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:42
| Melting point | 86.8°C |
|---|---|
| Boiling point | 533.8±50.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water, very soluble in ethanol (96 per cent) and in methylene chloride. |
| pka | 6.68±0.12(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | 0.37g/L(ambient temperature) |
| CAS DataBase Reference | 27220-47-9(CAS DataBase Reference) |
| EPA Substance Registry System | Econazole (27220-47-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36/37/39 |
Econazole Chemical Properties,Uses,Production
Chemical Properties
White or almost white powder
Uses
antineoplastic, anti-estrogen.
Econazole (Spectazole) is a synthetic imidazole. Econazole blocks C-14 demethylation of sterols, interfering with the biosynthesis of ergosterol, which results in disorganization of the fungal plasma cell membrane and increased permeability. It is active against dermatophytes, yeast, P. orbiculare, Aspergillus, Cladosporium, and Sporothrix.
Indications
Econazole (Spectazole) is a synthetic imidazole. Econazole blocks C-14 demethylation of sterols, interfering with the biosynthesis of ergosterol, which results in disorganization of the fungal plasma cell membrane and increased permeability. It is active against dermatophytes, yeast, P. orbiculare, Aspergillus, Cladosporium, and Sporothrix.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, econazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.
Antimicrobial activity
Broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.
Side effects
Local irritations such as itching and burning sensations and allergic reactions may occur in rare cases after topical therapy and are mainly due to the galenic formulation.
Solubility in organics
Econazole is soluble in methanol, acetic acid, and PEG 400; less soluble in ethanol, acetone, chloroform, and butanol; and barely soluble in water, ether, cyclohexane, and hexane.
Econazole Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Gufic Group | +91-2267261000 +91-2267261000 | Maharashtra, India | 22 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Clickchem Research LLP | +91-8140031133 +91-8140031133 | Gujarat, India | 411 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Rahil Chemie | 08068979865Ext 861 | Mumbai, India | 1 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
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