Isoconazole
- CAS No.
- 27523-40-6
- Chemical Name:
- Isoconazole
- Synonyms
- Isoconazol;soconazole;Isoconazole CRS;Einecs 248-508-3;Miconazole EP IMP D;24168-96-5 (Nitrate);Miconazole Impurity D;Isoconazole USP/EP/BP;Isoconazol [inn-spanish];Miconazole EP Impurity D
- CBNumber:
- CB0875200
- Molecular Formula:
- C18H14Cl4N2O
- Molecular Weight:
- 416.13
- MOL File:
- 27523-40-6.mol
- Modify Date:
- 2023/5/4 17:34:37
| Boiling point | 555.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent). |
| pka | 6?+-.0.12(Predicted) |
| CAS DataBase Reference | 27523-40-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H410 |
| Precautionary statements | P273-P391-P501 |
Isoconazole Chemical Properties,Uses,Production
Chemical Properties
White or almost white powder.
Uses
Antibacterial; antifungal.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, isoconazole is indicated for therapy of vulvovaginal mycoses causes by Candida species and Candida (Torulopsis) glabrata.
Antimicrobial activity
Broad-spectrum azole antimycotic with activity against almost all species of pathogenic fungi.
Pharmacokinetics
After topical application, isoconazole remains practically unabsorbed. Application in an ethanol/propyleneglycol vehicle increases penetration into the stratum corneum of the skin significantly.
Side effects
Local irritations such as itching and burning sensations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
Solubility in organics
Isoconazole is soluble in methanol, acetic acid, and PEG 400; less soluble in ethanol, acetone, chloroform, and butanol; and barely soluble in water, diethyl ether, cyclohexane, and hexane.
Isoconazole Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Clickchem Research LLP | +91-8140031133 +91-8140031133 | Gujarat, India | 411 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
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