2,4-Dichlorobenzyl alcohol
- CAS No.
- 1777-82-8
- Chemical Name:
- 2,4-Dichlorobenzyl alcohol
- Synonyms
- Myacide;Dybenal;myacidesp;Rapidosept;DYBENAL(R);RARECHEM AL BD 0019;2,4-Dichlorobenzyl a;Oxiconazole USP RC D;LABOTEST-BB LT01985654;Miconazole Impurity 14
- CBNumber:
- CB4156352
- Molecular Formula:
- C7H6Cl2O
- Molecular Weight:
- 177.03
- MOL File:
- 1777-82-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/4 20:11:12
| Melting point | 55-58 °C(lit.) |
|---|---|
| Boiling point | 150 °C (25 mmHg) |
| Density | 1.2970 (rough estimate) |
| vapor pressure | 0.154Pa at 25℃ |
| refractive index | 1.5756 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | 1g/l |
| pka | 13.60±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water, methanol and chloroform. |
| Merck | 14,3060 |
| BRN | 1448652 |
| InChIKey | DBHODFSFBXJZNY-UHFFFAOYSA-N |
| LogP | 2.8 at 24℃ |
| CAS DataBase Reference | 1777-82-8(CAS DataBase Reference) |
| EPA Substance Registry System | 2,4-Dichlorobenzenemethanol (1777-82-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H332-H412 | |||||||||
| Precautionary statements | P261-P271-P273-P280-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DO0890000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29062900 | |||||||||
| Toxicity | mouse,LD50,oral,2300mg/kg (2300mg/kg),Cosmetics and Toiletries. Vol. 95(6), Pg. 59, 1980. | |||||||||
| NFPA 704 |
|
2,4-Dichlorobenzyl alcohol price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 146668 | 2,4-Dichlorobenzyl alcohol 99% | 1777-82-8 | 50G | ₹5997.05 | 2022-06-14 | Buy |
| ALFA India | ALF-A13338-36 | 2,4-Dichlorobenzyl alcohol, 99% | 1777-82-8 | 500g | ₹18426 | 2022-05-26 | Buy |
| ALFA India | ALF-A13338-22 | 2,4-Dichlorobenzyl alcohol, 99% | 1777-82-8 | 100g | ₹9759 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D1837 | 2,4-Dichlorobenzyl Alcohol min. 97.0 % | 1777-82-8 | 25G | ₹2700 | 2022-05-26 | Buy |
| ALFA India | ALF-A13338-14 | 2,4-Dichlorobenzyl alcohol, 99% | 1777-82-8 | 25g | ₹2700 | 2022-05-26 | Buy |
2,4-Dichlorobenzyl alcohol Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powde
Uses
2,4-Dichlorobenzyl alcohol is an antiseptic found in commercially available throat lozenges. Also used deactivate Respiratory syncytial virus and SARS-Cov.
Definition
ChEBI: A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.
General Description
2,4-Dichlorobenzyl alcohol is a constituent of commercially available lozenges for acute sore throat caused by upper respiratory tract infections.
Mechanism of action
In-vitro evidence has demonstrated the virucidal effect of Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) on a number of viruses associated with the common cold; a reduction in viral load is believed to have benefits in reducing the symptoms. The local anesthetic action of AMC/DCBA throat lozenges, a combination of the potent channel blocker – AMC and the reduced potency for sodium channel blockade DCBA – attenuate the effects of AMC, possibly as a result of competitive binding, which acts on a sodium channel blocker, and may be effective in relieving symptoms due to inflammation. Therefore, AMC/DCBA throat lozenge is thought to represent a useful option to meet patients' needs and avoid unnecessary prescription of antibiotics[1].
Clinical Use
Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been marketed in many countries worldwide for pain relief in acute sore throat. Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been shown to be safe and efficient in relieving of acute sore throat symptoms, and it produces an immediate symptomatic relief. Local symptomatic pain relief plays an important role in managing acute sore throat[1-2].
Side effects
COMMON SIDE EFFECTS: Difficulty in breathing, Tongue soreness, Hypersensitivity reactions, Swelling of the face, Tongue, Throat and Neck.
References
[1] Ting W Tan. “Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol.” JBI database of systematic reviews and implementation reports (2017): 862–872.
[2] Thomas, Michael J. “ACP Journal Club. Amylmetacresol and 2, 4-dichlorobenzyl alcohol lozenges were better than placebo lozenges for relief of acute sore throat.” Annals of Internal Medicine 153 4 (2010): JC2-6.
2,4-Dichlorobenzyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| N S CHEMICALS AND CONSULTANTS PVT LTD | +91-9867708201 +91-9867708201 | Maharashtra, India | 18 | 58 | Inquiry |
| BENZO CHEM INDUSTRIES PVT LTD | +91-2243555888 +91-2243555888 | Mumbai, India | 68 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
| REDDY N REDDY PHARMACEUTICALS | +91-9848096759 +91-9848096759 | Hyderabad, India | 1989 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| SLN Pharmachem | +91-2228701926 +91-8655040421 | Maharashtra, India | 22 | 58 | Inquiry |
| Innovative Labs | +91-9885794886 +91-9885794886 | Telangana, India | 219 | 58 | Inquiry |
| Ar Ex Laboratories Pvt Ltd | 91-22-24454109 | Maharashtra, India | 18 | 58 | Inquiry |
| Bioxera Pharma Pvt. Ltd. | +91-2261842739 +91-2266862739 | Maharashtra, India | 20 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| N S CHEMICALS AND CONSULTANTS PVT LTD | 58 |
| BENZO CHEM INDUSTRIES PVT LTD | 58 |
| Allchem Lifescience Pvt. Ltd | 58 |
| REDDY N REDDY PHARMACEUTICALS | 58 |
| JSK Chemicals | 58 |
| Ralington Pharma | 58 |
| SLN Pharmachem | 58 |
| Innovative Labs | 58 |
| Ar Ex Laboratories Pvt Ltd | 58 |
| Bioxera Pharma Pvt. Ltd. | 58 |