Dichloroacetic acid
- CAS No.
- 79-43-6
- Chemical Name:
- Dichloroacetic acid
- Synonyms
- dichloro;dichloroacetic;2,2-Dichloroacetic acid;dca(acid);Aceticacid,dichloro-;DICHLOROACETICACID,REAGENT;DKhUK;urner’sliquid;Urner's liquid;oroacetic acid
- CBNumber:
- CB5671951
- Molecular Formula:
- C2H2Cl2O2
- Molecular Weight:
- 128.94
- MOL File:
- 79-43-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:27
| Melting point | 9-11 °C(lit.) |
|---|---|
| Boiling point | 194 °C(lit.) |
| Density | 1.56 g/mL at 25 °C (lit.) |
| vapor density | 4.5 (vs air) |
| vapor pressure | 0.19 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 1.48(at 25℃) |
| color | APHA: <50 |
| PH | 1.2 (129g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,3050 |
| BRN | 1098596 |
| Dielectric constant | 10.7（-7℃） |
| Exposure limits | ACGIH: TWA 0.5 ppm (Skin) |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Reacts with water. Protect from moisture. Hygroscopic. |
| InChIKey | JXTHNDFMNIQAHM-UHFFFAOYSA-N |
| LogP | 0.92 |
| CAS DataBase Reference | 79-43-6(CAS DataBase Reference) |
| IARC | 2B (Vol. 63, 84, 106) 2014 |
| NIST Chemistry Reference | Acetic acid, dichloro-(79-43-6) |
| EPA Substance Registry System | Dichloroacetic acid (79-43-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H311-H314-H351-H360FD-H373-H400 | |||||||||
| Precautionary statements | P202-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N,C,Xi,F | |||||||||
| Risk Statements | 36/38-40-50-35-36/37/38-67-38-65-48/20-11-63-50/53 | |||||||||
| Safety Statements | 26-45-61-36/37-36-16-62-36/37/39 | |||||||||
| RIDADR | UN 1764 8/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AG6125000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2915 40 00 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 orally in rats: 2.82 g/kg (Smyth) | |||||||||
| NFPA 704 |
|
Dichloroacetic acid price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D54702 | Dichloroacetic acid ReagentPlus?, ≥99% | 79-43-6 | 100ML | ₹3171.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D54702 | Dichloroacetic acid ReagentPlus?, ≥99% | 79-43-6 | 500ML | ₹9147.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D54702 | Dichloroacetic acid ReagentPlus?, ≥99% | 79-43-6 | 2.5L | ₹21877.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03541 | Dichloroacetic acid for synthesis | 79-43-6 | 5ML | ₹3190 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03541 | Dichloroacetic acid for synthesis | 79-43-6 | 250ML | ₹11740.01 | 2022-06-14 | Buy |
Dichloroacetic acid Chemical Properties,Uses,Production
Chemical Properties
Dichloroacetic acid, CHCI2COOH, also known as dichlorethanoic acid, is a corrosive, combustible, colorless, strong liquid acid with a pungent odor. It is soluble in water and alcohol. Dichloroacetic acid (Ka=5.14 × 10-2) is a stronger acid than chloroacetic acid. Most chemical reactions are similar to those of chloroacetic acid, although both chlorine atoms are susceptible to reaction. Dichloroacetic acid is much more stable to hydrolysis than chloroacetic acid. It is a reactive intermediate in organic synthesis. Dichloroacetic acid is prepared by the chlorination of acetic acid.
Uses
Dichloroacetic acid is used as an intermediate to make other chemicals such as its salts and esters. It is involved as a test reagent for fiber analysis and a disinfectant. It is used to inhibit mitochondrial PDK (pyruvate dehydrogenase kinase) and to shift cellular metabolism from glycolysis to glucose oxidation. Further, it is used in the treatment for post-ischemic recovery.
Definition
ChEBI: Dichloroacetic acid is an organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis. It has a role as an astringent and a marine metabolite. It is a monocarboxylic acid and an organochlorine compound. It derives from an acetic acid. It is a conjugate acid of a dichloroacetate.
Preparation
Dichloroacetic acid was reported to be first synthesized in 1864 by the further chlorination of monochloroacetic acid with chlorine (Beilstein Online, 2002). The most common production method for dichloroacetic acid is the hydrolysis of dichloroacetyl chloride, which is produced by the oxidation of trichloroethylene.
General Description
Dichloroacetic acid appears as a colorless crystalline solid melting at 49°F. Corrosive to metals and tissue.
Air & Water Reactions
Soluble in water.
Reactivity Profile
Dichloroacetic acid is probably hygroscopic. Dichloroacetic acid reacts with water or steam. Dichloroacetic acid is incompatible with strong oxidizing agents, strong bases and strong reducing agents.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Safety Profile
Moderately toxic by skin contact and ingestion. It is corrosive to the skin, eyes, and mucous membranes. Questionable carcinogen with experimental tumorigenic data. Will react with water or steam to produce toxic and corrosive fumes. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES.
Potential Exposure
This haloacetic acid can be a byproduct of drinking water disinfection and may increase the risk of cancer. This chemical is used as starting material for the production of glyoxylic; dialkyloxy acids; and sulfonamides. It is also used as a fungicide, a medication; and a chemical intermediate in pharmaceuticals
Shipping
UN1764 Dichloricacetic acid, Hazard class: 8; Labels: 8-Corrosive material.
Purification Methods
Crystallise this strong acid from *benzene or pet ether. Dry it with MgSO4 and fractionally distil it. [Bernasconi et al. J Am Chem Soc 107 3612 1985, Beilstein 2 IV 498.]
Incompatibilities
DCA is a medium strong acid; incompatible with nonoxidizing mineral acids; organic acids; bases, acrylates, aldehydes, alcohols, alkylene oxides; ammonia, aliphatic amines; alkanolamines, aromatic amines; amides, furfuryl alcohol (explosion hazard), glycols, isocyanates, ketones. Attacks metals generating flammable hydrogen gas. Attacks some plastics, rubber, and coatings
Dichloroacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bhakti Impex | +919822268653 | Pune, India | 76 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Chloritech Industries | +91-9227140314 +91-9227622171 | Gujarat, India | 11 | 58 | Inquiry |
| Vasant Chemicals Pvt Ltd | +919573466400 | Telangana, India | 18 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Bhakti Impex | 58 |
| JSK Chemicals | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Chloritech Industries | 58 |
| Vasant Chemicals Pvt Ltd | 58 |
| S D Fine Chem Limited | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |