Hemin
- CAS No.
- 16009-13-5
- Chemical Name:
- Hemin
- Synonyms
- HEMIN CHLORIDE;(-)-Syringaresnol-4-O-beta-D-apiofuranos;PROTOHEMIN IX;HEMIN PORCINE;FerriheMe chloride;HEMIN;HAEMIN;Hemin>Hemin,99%;Hemin, USP
- CBNumber:
- CB2409023
- Molecular Formula:
- C34H31ClFeN4O4-
- Molecular Weight:
- 650.94
- MOL File:
- 16009-13-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/30 16:33:02
| Melting point | 300 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | 1.4 M NaOH: soluble25mg/mL |
| form | crystal |
| color | black |
| Water Solubility | practically insoluble |
| Merck | 14,4644 |
| BRN | 5229914 |
| Exposure limits |
ACGIH: TWA 1 mg/m3 NIOSH: TWA 1 mg/m3 |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| InChIKey | BTIJJDXEELBZFS-HXFTUNQESA-K |
| SMILES | [Cl-][Fe+3]123[N-]4C5C(C)=C(C=C)C4=CC4C(C)=C(C=C)C(=CC6=C(C)C(CCC(=O)[O-])=C(C=C7C(CCC(=O)[O-])=C(C)C(C=5)=N17)[N-]26)N3=4.[H+] |
| EPA Substance Registry System | Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-5-13)- (16009-13-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H334 | |||||||||
| Precautionary statements | P261-P285-P304+P341-P342+P311-P403-P501c | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-22-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LJ8080000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
Hemin price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H9039 | Hemin from bovine, ≥90% | 16009-13-5 | 1G | ₹5910.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9039 | Hemin from bovine, ≥90% | 16009-13-5 | 10G | ₹40041.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9039 | Hemin from bovine, ≥90% | 16009-13-5 | 100G | ₹76770.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 51280 | Hemin BioXtra, from Porcine, ≥96.0% (HPLC) | 16009-13-5 | 1G | ₹4719.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 51280 | Hemin BioXtra, from Porcine, ≥96.0% (HPLC) | 16009-13-5 | 5G | ₹19333.45 | 2022-06-14 | Buy |
Hemin Chemical Properties,Uses,Production
Description
Hemin is a metalloporphyrin compound with a relatively simple structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is an in vitro group substitute of natural heme and its chemical properties are similar to that of heme. Heme, an essential small molecule in living organisms, can be found abundantly in various organisms including animals, plants, microorganisms, and algae.
Chemical Properties
Hemin is a Dark purple crystalline powder or elongated needle-shaped crystal. It does not dissolve in water, but it can dissolve in acidic acetone and alkaline water. The molecular formula is C34H32ClFe(III)N4O4, and the molecular weight is 651.96. Hemin is mainly used as raw material for anti-anemia and anti-cancer drugs.
Uses
Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture.
Application
Hemin is used for the following applications:
To study bacterial strains and growth conditions
Used in short-term colony assays (the culture medium consists of hemin along with other components)
Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.
General Description
Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin.
Purification Methods
Hemin is purified by recrystallisation from AcOH. Also, hemin (5g) is shaken in pyridine (25mL) till it dissolves, then CHCl3 (40mL) is added, the container is stoppered and shaken for 5minutes (releasing the stopper occasionally). The solution is filtered under slight suction, and the flask and filter are washed with a little CHCl3 (15mL). During this period, AcOH (300mL) is heated to boiling, and saturated aqueous NaCl (5mL) and conc HCl (4mL) are added. The CHCl3 filtrate is poured in a steady stream, with stirring, into the hot AcOH mixture and set aside for 12hours. The crystals are filtered off, washed with 50% aqueous AcOH (50mL), H2O (100mL), EtOH (25mL), Et2O and dried in air. [Fischer Org Synth Coll Vol III 442 1955, Beilstein 26 III/IV 3048.]
Hemin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Innovative | 07942565925 | Mumbai, India | 617 | 58 | Inquiry |
| Chempure | 08047626574 | Mumbai, India | 144 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Central Drug House(P) Ltd. | 58 |
| Triveni chemicals | 58 |
| Innovative | 58 |
| Chempure | 58 |
| Anand Agencies | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
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