Bethanechol
- CAS No.
- 590-63-6
- Chemical Name:
- Bethanechol
- Synonyms
- BETHANECHOL CHLORIDE;duvoid;Betanechol;Bthanechol chloride;Mictone;Uro-Carb;Mechotane;Mecothane;NSC 30783;-β-methyL
- CBNumber:
- CB8156880
- Molecular Formula:
- C7H17ClN2O2
- Molecular Weight:
- 196.68
- MOL File:
- 590-63-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
| Melting point | 187-190°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 1.7 g/mL stable for several days at 4°C. |
| form | crystalline |
| color | white |
| Merck | 14,1185 |
| CAS DataBase Reference | 590-63-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (590-63-6) |
Bethanechol price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C5259 | Carbamyl-β-methylcholine chloride ≥99% (TLC), crystalline | 590-63-6 | 5G | ₹11658.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2357 | Bethanechol Chloride Pharmaceutical Secondary Standard; Certified Reference Material | 590-63-6 | 300MG | ₹15598.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C5259 | Carbamyl-β-methylcholine chloride ≥99% (TLC), crystalline | 590-63-6 | 100G | ₹80841.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B4828 | Bethanechol Chloride | 590-63-6 | 5G | ₹3300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B4828 | Bethanechol Chloride | 590-63-6 | 25G | ₹10300 | 2022-05-26 | Buy |
Bethanechol Chemical Properties,Uses,Production
Description
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 μM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC50 = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Chemical Properties
White Solid
Uses
cholinergic
Definition
ChEBI: The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
General Description
Bethanechol, β-methylcholinechloride carbamate, (2-hydroxypropyl)trimethylammoniumchloride carbamate, carbamylmethylcholinechloride (Urecholine), is nonspecific in its action on muscarinicreceptor subtypes but appears to be more effective ateliciting pharmacological action of M3 receptors. It haspharmacological properties similar to those of methacholine.Both are esters of β-methylcholine and have feeblenicotinic activity. Bethanechol is inactivated more slowlyby AChE in vivo than is methacholine. It is a carbamyl esterand is expected to have stability in aqueous solutions similarto that of carbachol.
Hazard
Headache, flushing, gastrointestinal distress, diarrhea, hypotension, excessive salivation, sweating, hypersensitivity.
Mechanism of action
Bentanechol is a drug, which has structurally unique qualities of both methacholine and carbachol, i.e. it contains both β-methyl and carbamate functional groups, and quite logically exhibits pharmacological properties of both the drugs. It is resistant to hydrolysis by cholinesterases and has a very minor effect on nicotinic receptors of the autonomic ganglia and neuromuscular junctions. Betanechol has more of a selective action on muscarinic receptors of the gastrointestinal tract and the bladder than do other cholinic esters.
Clinical Use
The main use of bethanechol chloride is in the relief ofurinary retention and abdominal distention after surgery.The drug is used orally and by subcutaneous injection. Itmust never be administered by intramuscular or intravenousinjection because of the danger from cholinergic overstimulationand loss of selective action. Proper administration ofthe drug is associated with low toxicity and no serious sideeffects. Bethanechol chloride should be used with caution inasthmatic patients; when used for glaucoma, it producesfrontal headaches from the constriction of the sphinctermuscle in the eye and from ciliary muscle spasms. Its durationof action is 1 hour.
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JR Corporation | +91-9099076719 +91-7096568000 | Gujarat, India | 14 | 58 | Inquiry |
| Sanvin Group of Companies (Pioneer Agro Industries) | +91-2261066638 +91-2261066600 | Maharashtra, India | 27 | 58 | Inquiry |
| Globofarm International Private Limited | 91-22-49716506 | Maharashtra, India | 188 | 58 | Inquiry |
| Aadivighnesh Chem Private Ltd. | 91-22-28020015 | Maharashtra, India | 119 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Sanvin Group of Companies | 91-22-61066600 | Maharashtra, India | 16 | 58 | Inquiry |
| Atul Limited - PP Site | +91 2632 233261 | Gujarat, India | 23 | 58 | Inquiry |
| Shree Ganesh Pharmaceuticals | +91-22-2411 2010 | Maharashtra, India | 20 | 58 | Inquiry |
| Kromozome | 08069033777Ext 828 | Maharashtra, India | 45 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
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