Moclobemide
- CAS No.
- 71320-77-9
- Chemical Name:
- Moclobemide
- Synonyms
- Moclobemide (Ro 111163);4-chloro-N-(2-morpholinoethyl)benzamide;Manefix;CS-1682;manerix;aurorix;Moclaime;Moclamine;MODOBEMDE;Moclamide
- CBNumber:
- CB0281564
- Molecular Formula:
- C13H17ClN2O2
- Molecular Weight:
- 268.74
- MOL File:
- 71320-77-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/11 15:28:25
| Melting point | 137°C |
|---|---|
| Boiling point | 447.7±40.0 °C(Predicted) |
| Density | 1.206±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >20mg/mL |
| pka | 14.26±0.46(Predicted) |
| form | solid |
| color | white |
| Merck | 14,6226 |
| CAS DataBase Reference | 71320-77-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Moclobemide(71320-77-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xn,T+ | |||||||||
| Risk Statements | 22-37/38-41-26/27/28 | |||||||||
| Safety Statements | 26-39-45-36/37/39-22 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | CV2462000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 707 orally (Burkard, Wyss) | |||||||||
| NFPA 704 |
|
Moclobemide price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M3071 | Moclobemide ≥98% (HPLC), solid | 71320-77-9 | 10MG | ₹17168.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M3071 | Moclobemide ≥98% (HPLC), solid | 71320-77-9 | 50MG | ₹69323.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M2733 | Moclobemide | 71320-77-9 | 10MG | ₹10800 | 2022-05-26 | Buy |
Moclobemide Chemical Properties,Uses,Production
Description
Moclobemide is the first of a new generation of non-hydrazine, reversible MAO-A inhibitors useful in the treatment of depression. Moclobemide is a selective inhibitor of MAO-A, allowing tyramine to be metabolized by MAO-B. In controlled studies, moclobemide was clinically superior to desipramine and showed no cholinergic or cardiovascular side-effects. A metabolite is currently under investigation for treatment of Parkinson’s disease,.
Chemical Properties
White to Off-White Solid
Definition
ChEBI: A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
Drug interactions
Drug interactions for the RIMAs include interaction with SSRI antidepressants, which can cause the 5-HT syndrome. The effect of stimulant drugs, such as methylphenidate and dextroamphetamine (used to treat ADHD), may be increased. Some over-the-counter cold and hay fever decongestants (i.e., sympathomimetic amines) can have increased stimulant effects. Selegiline, a selective MAO-B used for Parkinson's disease, should not be used concurrently with the RIMAs. Unlike the irreversible MAOIs, no significant interactions with foods occur, because the selective inhibition of MAO-A does not stop the metabolism of tyramine. The RIMAs must not be taken concurrently with a nonreversible MAOI.
Moclobemide Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | China | 247 | 58 | Inquiry |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | China | 152 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
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