Citalopram
- CAS No.
- 59729-33-8
- Chemical Name:
- Citalopram
- Synonyms
- CELEXA;cipram;ZD-211;LU-10-171;Ciprarnil;NITALAPRAM;CITALOPRAM;Nitalapram HBr;Citalopram API;Citalopram base
- CBNumber:
- CB5244937
- Molecular Formula:
- C20H21FN2O
- Molecular Weight:
- 324.39
- MOL File:
- 59729-33-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/30 19:23:35
| Melting point | 156-157 °C |
|---|---|
| Boiling point | bp0.03 175-181° |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | pKa 9.38(H2O) (Uncertain) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 59729-33-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Citalopram(59729-33-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H335-H361-H317-H319-H410 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P273-P391-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P201-P202-P281-P308+P313-P405-P501 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
Citalopram Chemical Properties,Uses,Production
Description
Citalopram is a specific serotonin-uptake inhibitor useful in the treatment of depression. In endogenous depression citalopram was reported to be as effective as amitriptyline and mianserin, while being inferior to clomipramine in both endogenous and non-endogenous depression.
Uses
scabicide
Definition
ChEBI: A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Biological Functions
Citalopram (Celexa) has an elimination half-life of 35 hours and is 80% bound to plasma proteins. Of all of the SSRIs it has the least effect on the cytochrome P450 system and has the most favorable profile regarding drug–drug interactions.
General Description
Citalopram (Celexa) is a racemic mixture and is very SERTselective. The N-monodemethylated compound is slightlyless potent but is as selective. The aryl substituents are importantfor activity. The ether function is important andprobably interacts with the protonated amino group to givea suitable shape for SERT binding.
Biological Activity
Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC 50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors and is clinically used as an antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .
Citalopram Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Molkem Chemicals | +91-917228022464 +91-7228022464 | Ahmedabad, India | 138 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| Lavybens Pharma | +91-8790466757 +91-8790466756 | Telangana, India | 80 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Molkem Chemicals | 58 |
| J S LABS | 58 |
| Ipca Laboratories Ltd | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Besil Chem LLP | 58 |
| Alfa Omega Pharma | 58 |
| Lavybens Pharma | 58 |
| Mylan Laboratories Ltd | 58 |
| Vijaya Pharma And Life Science | 58 |
| AKASH PHARMA EXPORTS | 58 |
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