Escitalopram oxalate
- CAS No.
- 219861-08-2
- Chemical Name:
- Escitalopram oxalate
- Synonyms
- Cipralex;escitalopraM oxalat;(S)-Citalopram-d6 Oxalate;(1S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile Ethanedioate;CS-323;(S)-CITALOPRAM;EscitalopraM API;(S)-Citalopram-d6;ESCIFALOPRAMOXALATE;CitalopraM S-IsoMer
- CBNumber:
- CB5712919
- Molecular Formula:
- C22H23FN2O5
- Molecular Weight:
- 414.43
- MOL File:
- 219861-08-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/20 12:07:38
| Melting point | 152-153°C |
|---|---|
| alpha | D +12.31° (c = 1 in methanol) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥15mg/mL |
| form | powder |
| color | white to tan |
| Merck | 14,2318 |
| BCS Class | 1 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6) |
| InChIKey | KTGRHKOEFSJQNS-UHFFFAOYSA-N |
| SMILES | C1(CCCN(C)C)(C2=CC=C(F)C=C2)C2=C(C=C(C#N)C=C2)CO1.C(O)(=O)C(O)=O |
| CAS DataBase Reference | 219861-08-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | NP6333500 |
| HS Code | 29322090 |
Escitalopram oxalate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E4786 | Escitalopram oxalate ≥98% (HPLC), powder | 219861-08-2 | 10MG | ₹10110.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1733 | Escitalopram Oxalate Pharmaceutical Secondary Standard; Certified Reference Material | 219861-08-2 | 1G | ₹22591.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E4786 | Escitalopram oxalate ≥98% (HPLC), powder | 219861-08-2 | 50MG | ₹38829.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0958 | (S)-Citalopram Oxalate | 219861-08-2 | 200MG | ₹6400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E0958 | (S)-Citalopram Oxalate | 219861-08-2 | 1G | ₹10200 | 2022-05-26 | Buy |
Escitalopram oxalate Chemical Properties,Uses,Production
Description
Escitalopram was launched as Cipralex? in Switzerland, Sweden and UK for the treatment of depression and panic disorder. It is the S-enantiomer version of the selective serotonin reuptake inhibitor (SSRI) citalopram approved in 1989. It can be obtained from 5cyanophthalide by successive reactions with 4-fluorophenyl magnesium bromide and 3-(dimethylamino)propyl magnesium chloride. The resulting racemic diol can be resolved by several routes such as crystallization with a chiral acid. Finally, a two step cyclisation procedure affords escitalopram. Escitalopram is twice as effective as the racemate and over 100 fold more potent than the R-enantiomer in inhibiting the 5HT reuptake in vivo in rat brain synaptosomes. Moreover, it exhibits higher selectivity for the human serotonin transporter relative to the noradrenaline or dopamine transporters than any other currently available SSRl’s. In the mouse forced swim test, the duration of immobility (which reflects antidepressant activity) for escitalopram was comparable to citalopram and greater than (R)-citalopram. Clinical trials in patients with panic disorders or depression have shown that escitalopram has a clinically relevant and significant effect. Additionally, it has a faster onset of antidepressant action than citalopram. Escitalopram has linear pharmacokinetics, with a long half-life (27-32 h). It is extensively metabolized in the liver via cytochromes P450 to S(+)-desmethyl and S(+)-didesmethyl citalopram. However, it has been shown to be a weak or negligible inhibitor of CYP450 drugmetabolizing enzymes in vitro. Escitalopram is well tolerated with nausea being the most common side effect.
Chemical Properties
White Solid
Uses
Escitalopram oxalate may be used as a pharmaceutical primary standard for the quantification of the analyte in pharmaceutical formulations using analytical techniques.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Escitalopram Oxalate, a highly selective serotonin re-uptake inhibitor antidepressant, is a pure S-enantiomer of the racemic, bicyclic pthalates derivatives of citalopram. It is mainly developed for the treatment of depression and anxiety disorders.
Mechanism of action
Escitalopram is the S-enantiomer of citalopram and is the most selective of SSRIs. SSRIs' mechanism of action is exerted by binding to the sodium-dependant serotonin transporter protein (SERT) located in the presynaptic neuron. SERT works by re-uptaking serotonin from the synaptic cleft to the presynaptic neuron. When SERT is inactivated by escitalopram, this increases the amount of serotonin in the synaptic cleft.
Side effects
The main side effect of escitalopram include: Nausea, dry mouth, trouble sleeping, constipation, tiredness, drowsiness, dizziness, and increased sweating may occur.
Escitalopram oxalate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 54 | 58 | Inquiry |
| Viruj Pharmaceuticals Pvt Ltd | +91-9441591589 +91-9441591589 | Hyderabad, India | 33 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| TYNDAL LABS PVT LTD | +91-8008166674 +91-8008166674 | AndhraPradesh, India | 95 | 58 | Inquiry |
| Vadivarhe Speciality Chemicals Limited | +91-9028832204 +91-9028832204 | Maharashtra, India | 38 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| CVR Life sciences Pvt Ltd | +91-7386789224 +91-9912960099 | Hyderabad, India | 22 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
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