Escitalopram
- CAS No.
- 128196-01-0
- Chemical Name:
- Escitalopram
- Synonyms
- Seroplex;Escitalopram;Escitalopram CRS;EscitalopraM Oxalate INN;Escitalopram Impurity 31;(S)-(+)-CITALOPRAM OXALATE;(+)-(S)-Citalopram Oxalate;(+)-(S)-Citalopram-d4 Oxalate;Escitalopram oxalate impurity III;Escitalopram(Escitalopram Oxalate)
- CBNumber:
- CB2712918
- Molecular Formula:
- C20H21FN2O
- Molecular Weight:
- 324.39
- MOL File:
- 128196-01-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/16 15:32:52
| alpha | D +12.33° (c = 1 in methanol) |
|---|---|
| Boiling point | 428.3±45.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 9.57±0.28(Predicted) |
| color | Off-white to light yellow |
| CAS DataBase Reference | 128196-01-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H302 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Escitalopram Chemical Properties,Uses,Production
Uses
antidepressive;selective serotonin reuptake inhibitor
Definition
ChEBI: A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.
Mechanism of action
Escitalopram is the S-enantiomer of citalopram that binds with high affinity and selectivity to the human SERT equivalent to (±)-citalopram. It has been reported that nearly all the activity resides in the S-enantiomer and that R-citalopram actually counteracts the action of the S-enantiomer. Studies show that escitalopram exhibits twice the activity of citalopram and is at least 27 times more potent than the R-enantiomer. The R-enantiomer inhibits the S-enantiomer at the transporter. Escitalopram's mechanism of action is common to the SSRIs.
Pharmacokinetics
The pharmacokinetics for escitalopram does not exhibit stereoisomer selectivity and, therefore, is similar to that for citalopram. Likewise, it exhibits linear pharmacokinetics so that plasma levels increase proportionately and predictably with increased doses, and its half-life of 27 to 32 hours is consistent with once-daily dosing. It also has been found that R-citalopram is cleared more slowly than the S-enantiomer. Therefore, when the drug is used as a racemic mixture (citalopram), the inactive isomer predominates at steady state. This is an added incentive for use of the enantiomerically pure escitalopram. Escitalopram has negligible effects on CYP isoforms, suggesting a low potential for drug–drug interactions. Escitalopram is indicated for patients with major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder.
Escitalopram Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 195 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 159 | 58 | Inquiry |
| Vachichem | +91-9886704423 +91-9880599557 | Karnataka, India | 72 | 58 | Inquiry |
| Kekule Pharma Limited | +919849798889 | Hyderabad, India | 59 | 58 | Inquiry |
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| Lavybens Pharma | +91-8790466757 +91-8790466756 | Telangana, India | 80 | 58 | Inquiry |
| Ratnagene lifescience Pvt Ltd | +91-8168821744 +91-7043984089 | Gujarat, India | 26 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Vraj Medicines | 08048985020 | Gujarat, India | 3 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANWITA APIS | 58 |
| J S LABS | 58 |
| Vachichem | 58 |
| Kekule Pharma Limited | 58 |
| Alfa Omega Pharma | 58 |
| Lavybens Pharma | 58 |
| Ratnagene lifescience Pvt Ltd | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Vraj Medicines | 58 |
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