Doxapram hydrochloride monohydrate
- CAS No.
- 7081-53-0
- Chemical Name:
- Doxapram hydrochloride monohydrate
- Synonyms
- stimulexin;DOXAPRAM HCL;DoxapraM HCL API;Doxapram Hydrochoride;DOXAPRAM HYDROCHLORIDE;Doxapram hydrochloride CRS;DoxapraM Hydrochloride, USP;doxapramhydrochloridehydrate;Dopram hydrochloride hydrate;Doxapram hydrochloride monohyd
- CBNumber:
- CB6189200
- Molecular Formula:
- C24H30N2O2.ClH.H2O
- Molecular Weight:
- 432.99
- MOL File:
- 7081-53-0.mol
- Modify Date:
- 2024/7/2 8:55:13
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| HS Code | 2934990002 | |||||||||
| Toxicity | LD50 orally in rats: 261 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
|
Doxapram hydrochloride monohydrate Chemical Properties,Uses,Production
Description
Doxapram is a central respiratory stimulant. It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.
Chemical Properties
White or almost white, crystalline powder.
Uses
antibacterial
Definition
ChEBI: The monohydrate form of doxapram hydrochloride. A central and respiratory stimulant with a brief duration of action, it is used as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, nd of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
General Description
Doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate (Dopram), has an obscuremolecular mechanism of action. Overall, it stimulatesrespiration by action on peripheral carotid chemoreceptors.It has use as a respiratory stimulant postanesthetically, afterCNS depressant drug overdose, in chronic obstructive pulmonarydiseases, and in the apneas. Dopram is administeredexclusively by intravenous injection. Because of the benzylalcohol content of the injectable formulation, Dopram mustnever be given to neonates.
Doxapram hydrochloride monohydrate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Stellar Chemical Laboratories Pvt., Ltd. | +91-66662691 +91-2266662690 | Maharashtra, India | 11 | 58 | Inquiry |
| Khandelwal Laboratories Private Limited | +91-2249252828 +91-2223724214 | Maharashtra, India | 22 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CAD Pharma Inc | 08048372459Ext 215 | Karnataka, India | 12 | 58 | Inquiry |
| Khandelwal Laboratories Private Limited | 09819064588 | Mumbai, India | 5 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21663 | 55 | Inquiry |
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