Minoxidil
- CAS No.
- 38304-91-5
- Chemical Name:
- Minoxidil
- Synonyms
- Minoxidil Base;pdp;Minoxidil powder;2,4-diamino-6-piperidinopyrimidine3-n-oxide;rogaine;minoxidi;Minoxidil CRS;4-pyrimidinediamine;Minoxidil for system suitability;Minoxidil for system suitability CRS
- CBNumber:
- CB7383531
- Molecular Formula:
- C9H15N5O
- Molecular Weight:
- 209.25
- MOL File:
- 38304-91-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/22 14:21:17
| Melting point | 272-274 °C (dec.) (lit.) |
|---|---|
| Boiling point | 348.61°C (rough estimate) |
| Density | 1.1651 (rough estimate) |
| refractive index | 1.7610 (estimate) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, soluble in methanol and in propylene glycol. |
| pka | 4.61(at 25℃) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol. |
| Merck | 14,6203 |
| BCS Class | 3 |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | ZFMITUMMTDLWHR-UHFFFAOYSA-N |
| CAS DataBase Reference | 38304-91-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Minoxidil(38304-91-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T+ | |||||||||
| Risk Statements | 22-36/37/38-26/27/28 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UV8200000 | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra) | |||||||||
| NFPA 704 |
|
Minoxidil price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M4145 | Minoxidil ≥99% (TLC) | 38304-91-5 | 25MG | ₹7739.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M4145 | Minoxidil ≥99% (TLC) | 38304-91-5 | 100MG | ₹18889.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M4145 | Minoxidil ≥99% (TLC) | 38304-91-5 | 250MG | ₹41871.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2123 | Minoxidil Pharmaceutical Secondary Standard; Certified Reference Material | 38304-91-5 | 200MG | ₹15847.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M4145 | Minoxidil ≥99% (TLC) | 38304-91-5 | 500MG | ₹84738.1 | 2022-06-14 | Buy |
Minoxidil Chemical Properties,Uses,Production
Description
Minoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.
Chemical Properties
White Crystalline Solid
Uses
Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels
Definition
ChEBI: Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a pyrimidine N-oxide, a member of piperidines and an aminopyrimidine.
General Description
Minoxidil, 2,4-diamino-6-piperidinopyrimidine-3-oxide . It is converted to minoxidil sulfate in the liver bya sulfotransferase enzyme.
The antihypertensive properties of minoxidil are similarto those of hydralazine hydrochloride, in that minoxidil candecrease arteriolar vascular resistance. Minoxidil exerts itsvasodilatory action by a direct effect on arteriolar smoothmuscle and appears to have no effect on the CNS or on theadrenergic nervous system in animals. The serum half-lifeis 4.5 hours, and the antihypertensive effect may last up to24 hours.
Biological Activity
Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.
Pharmacokinetics
Minoxidil is absorbed from the GI tract and is metabolized to its active sulfate metabolite. Plasma concentrations for minoxidil sulfate peak within 1 hour and then decline rapidly. Following an oral dose of minoxidil, its hypotensive effect begins in 30 minutes, is maximal in 2 to 8 hours, and persists for approximately 2 to 5 days. The delayed onset of the hypotensive effect for minoxidil is attributed to its metabolism to its active metabolite. The drug is not bound to plasma proteins. The major metabolite for minoxidil is its N-O-glucuronide, which unlike the sulfate metabolite is inactive as a hypotensive agent. Approximately 10 to 20% of an oral dose of minoxidil is metabolized to its active metabolite, minoxidil O-sulfate, and approximately 20% of minoxidil is excreted unchanged.
Clinical Use
Minoxidil is used for severe hypertension that is difficultto control with other antihypertensive agents. The drug hassome of the characteristic side effects of direct vasodilatorydrugs. It causes sodium and water retention and may requirecoadministration of a diuretic. Minoxidil also causes reflextachycardia, which can be controlled by use of a -adrenergicblocking agent.
Minoxidil topical solution is used to treat alopecia androgenitica(male-pattern baldness). Although the mechanismis not clearly understood, topical minoxidil is believed to increasecutaneous blood flow, which may stimulate hairgrowth. The stimulation of hair growth is attributed to vasodilationin the vicinity of application of the drug, resultingin better nourishment of the local hair follicles.
Side effects
Adverse reactions include local irritation and contact dermatitis. If the treatment is discontinued, clinical regression occurs within 3 months to the state of hair thinning that would have occurred had the treatment not been started. Twice-daily treatment is more efficacious than once-daily application. Women who use the5%concentrationmay note the development of facial hair, which is reversible on discontinuation of the medication. The 5% concentration can be more irritating than the 2% solution.
Drug interactions
When minoxidil is administered with diuretics or other hypotensive drugs, the hypotensive effect of minoxidil increases, and concurrent use may cause profound orthostatic hypotensive effects.
Minoxidil Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Global Pharma | +91-9819994077 +91-9819994077 | Maharashtra, India | 34 | 58 | Inquiry |
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| Integrin Life Sciences. Pvt. Ltd. | +91-4040265469 +91-9849990870 | Hyderabad, India | 90 | 58 | Inquiry |
| Dayaram Pharma Chem | +91-9601766800 +91-9601766800 | Gujarat, India | 61 | 58 | Inquiry |
| Synergene Active Ingredients Pvt. Ltd. | +91-04023700774 +91-04023700774 | Telangana, India | 96 | 58 | Inquiry |
| Vachichem | +91-9886704423 +91-9880599557 | Karnataka, India | 72 | 58 | Inquiry |
| Dinakara Life Sciences Private Limited | +91-4048553395 +91-8668856516 | Telangana, India | 25 | 58 | Inquiry |
| Global Calcium Pvt Ltd | +91-8050750904 +91-8040554500 | Karnataka, India | 132 | 58 | Inquiry |
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