Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >API >Urinary System Drugs >Other Urinary System Drugs >Finasteride

Finasteride

Finasteride Structure
CAS No.
98319-26-7
Chemical Name:
Finasteride
Synonyms
PROSCAR;Finasteride for peak identification;n-tert-butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide;MK-906;Andozac;mk-0906;Fistide;PROSTIDE;FINASTID;Propecia
CBNumber:
CB9433852
Molecular Formula:
C23H36N2O2
Molecular Weight:
372.54
MOL File:
98319-26-7.mol
Modify Date:
2024/7/24 13:33:21
Request For Quotation

Finasteride Properties

Melting point 253 °C
alpha 405 -59° (c = 1 in methanol)
Boiling point 576.6±50.0 °C(Predicted)
Density 1.065±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: 32 mg/mL, soluble
form solid
pka 14.17±0.70(Predicted)
color white to beige
Water Solubility insoluble
Merck 14,4082
BCS Class 1
InChIKey DBEPLOCGEIEOCV-WSBQPABSSA-N
LogP 3.030
CAS DataBase Reference 98319-26-7(CAS DataBase Reference)
EPA Substance Registry System 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)- (98319-26-7)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H360FD
Precautionary statements  P202-P264-P270-P280-P301+P312-P308+P313
Hazard Codes  Xn,T,Xi
Risk Statements  22-61-60-36/37/38
Safety Statements  36/37/39-45-53-36-26-24/25
WGK Germany  3
RTECS  CL5245000
HS Code  29379000
NFPA 704
0
2 0

Finasteride price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) F1293 Finasteride ≥98% (HPLC), powder 98319-26-7 100MG ₹11745.13 2022-06-14 Buy
Sigma-Aldrich 34202 Finasteride VETRANAL?, analytical standard 98319-26-7 100MG ₹19149.43 2022-06-14 Buy
Sigma-Aldrich(India) 34202 Finasteride VETRANAL?, analytical standard 98319-26-7 100MG ₹19149.43 2022-06-14 Buy
TCI Chemicals (India) F0675 Finasteride min. 98.0 % 98319-26-7 200MG ₹6000 2022-05-26 Buy
TCI Chemicals (India) F0675 Finasteride min. 98.0 % 98319-26-7 1G ₹14100 2022-05-26 Buy
Product number Packaging Price Buy
F1293 100MG ₹11745.13 Buy
34202 100MG ₹19149.43 Buy
34202 100MG ₹19149.43 Buy
F0675 200MG ₹6000 Buy
F0675 1G ₹14100 Buy

Finasteride Chemical Properties,Uses,Production

Description

Finasteride, a novel 4-azasteroid, is a breakthrough in the treatment and control of benign prostatic hyperplasia. Mechanistically, it inhibits the prostatic-specific enzyme 5-alpha reductase, thereby decreasing the conversion of testosterone to dihydrotestosterone. It is reportedly effective in reducing urinary symptoms and prostatic volume and increasing maximal urinary flow rate. Finasteride is also being investigated as a treatment for prostatic cancer.

Chemical Properties

White or off-white crystalline powder. Soluble in chloroform, dimethyl sulfoxide, ethanol, methanol, or n-propanol. Insoluble in propylene glycol or polyethylene glycol 400. Very slightly soluble in 0.1mol/L hydrochloric acid, 0.1mol/L sodium hydroxide solution, or water.

Uses

Finasteride is an antialopecia agent that Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. It is used to treatment of benign prostatic hyperplasia and androgenetic alopecia.

Indications

Finasteride (Proscar) is a 5-reductase inhibitor that blocks the conversion of testosterone to DHT in target tissues. Since DHT is the major intracellular androgen in the prostate, finasteride is effective in suppressing DHT stimulation of prostatic growth and secretory function without markedly affecting libido. It is approved for the treatment of benign prostatic hyperplasia. Although there is usually some regression in the size of the prostate gland following administration of finasteride, clinical response may take 6 to 12 months. If the obstructive symptoms are severe, there is often not enough time to allow this compound to work.The principal adverse effects of finasteride are impotence, decreased libido, and decreased volume of ejaculate. The compound is generally well tolerated in men.

Definition

ChEBI: Finasteride is an aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia. It has a role as an androgen antagonist, an EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor and an antihyperplasia drug. It is an aza-steroid, a 3-oxo steroid and a delta-lactam. It derives from a hydride of a 5alpha-androstane.

Application

Finasteride is a specific inhibitor of steroid type II 5α-reductase, an intracellular enzyme that converts testosterone to DHT. By inhibiting type II 5α-reductase, this conversion is blocked, resulting in significant decreases in serum and tissue DHT concentrations. Merck & Co. developed finasteride as an oral treatment for androgenetic alopecia after men taking finasteride (5 mg/ day) for prostate enlargement noticed regrowth of their hair. Finasteride is indicated for use in men only. Women of childbearing age cannot take finasteride because it may cause hypospadia (a developmental abnormality of the penis) in the male offspring if taken during pregnancy.

Biological Activity

Antiandrogen that inhibits type II 5 α reductase (IC 50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo . Orally active.

Pharmacokinetics

The mean oral bioavailability of finasteride is 65%, as shown in Table 45.4, and is not affected by food. Approximately 90% of circulating finasteride is bound to plasma proteins. Finasteride has been found to cross the blood-brain barrier, but levels in semen were undetectable (<0.2 ng/mL). Finasteride is extensively metabolized in the liver, primarily via CYP3A4 to two major metabolites: monohydroxylation of the t-butyl side chain, which is further metabolized via an aldehyde intermediate to the second metabolite, a monocarboxylic acid. The metabolites show approximately 20% the inhibition of finasteride for 5α-reductase. The mean terminal half-life is approximately 5 to 6 hours in men between 18 and 60 years of age and 8 hours in men older than 70 years of age. Following an oral dose of finasteride, approximately 40% of the dose was excreted in the urine as metabolites and approximately 57% in the feces. Even though the elimination rate of finasteride is decreased in the elderly, no dosage adjustment is necessary. No dosage adjustment is necessary in patients with renal insufficiency. A decrease in the urinary excretion of metabolites was observed in patients with renal impairment, but this was compensated for by an increase in fecal excretion of metabolites. Caution should be used during administration to patients with liver function abnormalities, because finasteride is metabolized extensively in the liver.

Clinical Use

The selective inhibition of the type 2 5α-reductase isozyme produces a rapid reduction in plasma DHT concentration, reaching 65% suppression within 24 hours of administering a 1-mg oral tablet (106). At steady state, finasteride suppresses DHT levels by approximately 70% in plasma and by as much as 85 to 90% in the prostate. The remaining DHT in the prostate likely is the result of type 1 5α-reductase. The mean circulating levels of testosterone and estradiol remained within their physiological concentration range. Long-term therapy with finasteride can reduce clinical significant end points of BPH, such as acute urinary retention or surgery. Finasteride is most effective in men with large prostates. Finasteride has no affinity for the AR and no androgenic, antiandrogenic, estrogenic, antiestrogenic, or progestational effects.

References

Perifollicular fibrosis: Pathogenetic role in androgenetic alopecia; H.G. Yoo, et al.; Biol. Pharm. Bull. 29, 1246 (2006). DOI:10.1248/BPB.29.1246
Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line: J.M. Golbano, et al.; Int. J. Oncol. 32, 919 (2008) DOI:10.3892/IJO.32.4.919
Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders: S. Paba, et al.; Curr. Pharm. Des. 17, 151 (2011) DOI:10.2174/138161211795049589
Finasteride: An update of its use in the management of symptomatic benign prostatic hyperplasia (a review). M. I. Wilde, K. L. Goa, Drugs 1999, 57, 557. DOI:10.2165/00003495-199957040-00008
Finasteride: a review of its use in male pattern hair loss. K. J. McClellan, A. Markham, Drugs 1999, 57, 111. DOI:10.2165/00003495-199957010-00014
Type 1 and type 2 5α-reductase expression in the development and progression of prostate cancer (a review). L. N. Thomas, R. C. Douglas, C. B. Lazier, C. K. L. Too, R. S. Rittmaster, D. J. Tindall, Eur. Urol. 2008, 53, 244. DOI:10.1016/J.EURURO.2007.10.052

Finasteride Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID Platinum dioxide Pregnenolone Sodium iodate Aluminium isopropoxide
2,2'-Dithiodipyridine tert-Butanol Potassium hydroxide solution Potassium permanganate Ethylene glycol
Cyclohexanone Triphenylphosphine Sodium carbonate tert-Butylamine Ethylmagnesium bromide
chevron_left

1of3

chevron_right

Preparation Products

Finasteride Suppliers

Global( 786)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
PANCHSHEEL ORGANICS LTD +91-9821053955 +91-9324201019 Mumbai, India 82 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Horster Biotek Pvt Ltd +91-7359657360 +91-9898127219 Gujarat, India 58 58 Inquiry
Aurobindo Pharma Limited +914066725000 Telangana, India 112 58 Inquiry
Cipla Ltd +912224826000 Maharashtra, India 133 58 Inquiry
Afton Pharma +91-9712000202 +91-9712000202 Gujarat, India 63 58 Inquiry
Swati Spentose Pvt Ltd +91-2261505232 +91-2261505232 Maharashtra, India 44 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Dy - Mach Pharma +91-2265018321 +91-2226833227 Maharashtra, India 18 58 Inquiry
Aspen Biopharma Labs Pvt Ltd +91-9248058660 +91-9248058662 Telangana, India 234 58 Inquiry
Supplier Advantage
PANCHSHEEL ORGANICS LTD 58
Hetero Drugs Limited 58
Horster Biotek Pvt Ltd 58
Aurobindo Pharma Limited 58
Cipla Ltd 58
Afton Pharma 58
Swati Spentose Pvt Ltd 58
Ralington Pharma 58
Dy - Mach Pharma 58
Aspen Biopharma Labs Pvt Ltd 58

Related articles

Finasteride Spectrum

Finasteride(98319-26-7)1HNMR

98319-26-7(Finasteride)Related Search:

Chlorantraniliprole Methylparaben Methanol Formamide Basic Violet 1
Methyl acrylate N,N-Dimethylformamide Kresoxim-methyl Propyl gallate Paraquat dichloride
Acetonitrile Propyl butyrate Minoxidil Methyl Intermediate of finasteride
Dihydroproscar N.O-Bis(Trimethylsilyl)Trifluoroacetamide(Bstfa),Finasteride LAPISTERIDE
chevron_left

1of4

chevron_right
(5alpha,17beta)-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide 17beta-(n-tert-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one 4-azaandrost-1-ene-17-carboxamide,n-(1,1-dimethylethyl)-3-oxo-,(5-alpha,17-be 4-azaandrost-1-ene-17-carboxamide,n-(1,1-dimethylethyl)-3-oxo-,(5alpha,17beta l-652,931 mk-0906 (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide (5α，17β)-N-(1，1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide Andozac Chibrcr-Proscar Firmstid：Prostide 1,(5-ALPHA)-ANDROSTAN-4-AZA-3-ONE-17-BETA-(N-TERT-BUTYL-CARBOXAMIDE) 17BETA-(T-BUTYLCARBAMOYL)-4-AZA-5-ALPHA-ANDROSTEN-3-ONE Finastride N-(1,1-Dimethylethyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide Finasteride,N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, MK-906, N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide Finasteride (200 mg) Finasteride,Proscar (1S,2R,7R,10S,11S,14S,15S)-N-tert-butyl-2,15-diMethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxaMide (5α,17β)-N-(1,1-DiMethylethyl)-3-oxo- Finasteride API N-(2-METHYL-2-PROPYL)-3-OXO-4-AZA-5ALPHA-ANDROST-1-ENE-17BETA-CARBOXAMIDE MK-906 Fistide Prosteride PROSTIDE 4A,6A,11A-TRIMETHYL-2-OXO-2,4A,4B,5,6,6A,7,8,9,9A,9B,10,11,11A-TETRADECAHYDRO-1H-INDENO[5,4-F]QUINOLINE-7-CARBOXYLIC ACID TERT-BUTYLAMIDE (4AR,4BS,6AS,7S,9AS,9BS,11AR)-4A,6A-DIMETHYL-2-OXO-2,4A,4B,5,6,6A,7,8,9,9A,9B,10,11,11A-TETRADECAHYDRO-1H-INDENO[5,4-F]QUINOLINE-7-CARBOXYLIC ACID TERT-BUTYLAMIDE FINASTID FINASTERIDE N-Tert-Butyl-3-Oxo-4-Aza-5alpha-Androst-1-Ene-17be Finasteride, Vetranal MK-906, Proscar, Prostide, Finastid, n-tert-butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide FINASTERIDE,USP (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide N-tert-butyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide FinasterideEdmf/Gmp FinasterideEdmf/Gmp,Usp29/Ep5 N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-en-17beta-carboxamide (5a,17)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide Norandrostenediol THP Ether Vitamin B1 HCL (Thiamine Hcl) MK-906, N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide (1S,9aR,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide Finasteride, 98%, an orally active testosterone 5-alpha-reductase inhibitor (1S,3aS,3bS,5aR,9aR,9bS,11aS)-9a,11a-dimethyl-N-(2-methylpropyl)-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide Finasteride CRS 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)- fenasteride Finasteride USP/EP/BP (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a -dimethyl-2-oxo-1H,2H,4aH,4bH,5H,6H,6aH,7H,8H, 9H,9aH,9bH,10H,11H,11aH-indeno[5,4-f]quinoline- 7-carboxamide Finasteride (MK-906) Finasteride (Proscar)-1 gram(54) FinasterideQ: What is Finasteride Q: What is the CAS Number of Finasteride Q: What is the storage condition of Finasteride Q: What are the applications of Finasteride Finasteride (1270402)