3-Chloroperoxybenzoic acid
- CAS No.
- 937-14-4
- Chemical Name:
- 3-Chloroperoxybenzoic acid
- Synonyms
- M-CPBA;M-CHLOROPERBENZOIC ACID;3-CHLOROPERBENZOIC ACID;M-CHLOROPEROXYBENZOIC ACID;3-chlorobenzoperoxoic acid;3-Chlorobenzenecarboperoxoic acid;3-Chloroperoxybenzoic Acid (MCPBA);3-ChL;M-Chloroperoxybenzoic;65.0%(T)
- CBNumber:
- CB4259408
- Molecular Formula:
- C7H5ClO3
- Molecular Weight:
- 172.57
- MOL File:
- 937-14-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 12:20:35
| Melting point | 69-71 °C(lit.) |
|---|---|
| Boiling point | 244.67°C (rough estimate) |
| Density | 0.56 |
| vapor pressure | 0.373Pa at 25℃ |
| refractive index | 1.4580 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 7.57 (in water @ 25 °C) |
| form | Moist Powder |
| color | White |
| PH | 4.5@25 °C (saturated aq. sol) |
| Odor | slight pungent odor |
| Water Solubility | insoluble |
| Decomposition | >88 °C |
| BRN | 608317 |
| Stability | Strong oxidizing agent - contact with combustible material may cause fire. May be shock or heat sensitive. Incompatible with organic materials, strong reducing agents. |
| InChIKey | NHQDETIJWKXCTC-UHFFFAOYSA-N |
| LogP | 1.03 at 25℃ |
| CAS DataBase Reference | 937-14-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Chloroperbenzoic acid(937-14-4) |
| EPA Substance Registry System | Benzenecarboperoxoic acid, 3-chloro- (937-14-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H242-H315-H317-H319-H335 | |||||||||
| Precautionary statements | P210-P235-P280-P302+P352-P370+P378-P410 | |||||||||
| Hazard Codes | O,Xi,C | |||||||||
| Risk Statements | 5-8-36/37/38-43-7-34-22 | |||||||||
| Safety Statements | 17-26-36/37-45-36/37/39-3/7-14-27-7/9 | |||||||||
| RIDADR | UN 3106 5.2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SD9470000 | |||||||||
| F | 4.4 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 5.2 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3-Chloroperoxybenzoic acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 273031 | 3-Chloroperbenzoic acid ≤77% | 937-14-4 | 25G | ₹2280 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 273031 | 3-Chloroperbenzoic acid ≤77% | 937-14-4 | 100G | ₹4540 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 273031 | 3-Chloroperbenzoic acid ≤77% | 937-14-4 | 500G | ₹17380 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 273031 | 3-Chloroperbenzoic acid ≤77% | 937-14-4 | 1KG | ₹50725.95 | 2022-06-14 | Buy |
| ottokemi | C 2142 | meta-Chloroperoxybenzoic acid 50-55% | 937-14-4 | 100gm | ₹2061 | 2022-05-26 | Buy |
3-Chloroperoxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White moist powder
Uses
3-Chloroperoxybenzoic acid is a strong oxidizing agent used in the oxidation reactions such as aldehydes and ketones to esters (Bayer-Villiger-Oxidation), olefines to epoxides, sulfides to sulfoxides and sulfones, and amines to nitroalkanes, N-oxides.
Reactions
3-Chloroperoxybenzoic acid (MCPBA) is one of the most popular oxidation reagent in organic synthesis, because of its outstanding performance in terms of:
reactivity, combined with reducing the number of reaction steps in classical synthetic routes,
regio- and stereoselectivity,
protection of functional groups mostly not required,
high purity and yields.
Its literature covers a huge area of different syntheses and below reaction equations just can be a brief overview of its interesting applications:
General Description
3-Chloroperoxybenzoic acid is sensitive to heat. Storage of 3-Chloroperoxybenzoic acid must be done so with stringent temperature control measures. It's explosion hazard is also mitigated by mixing the peroxide in a solvent slurry.
Reactivity Profile
May explode from heat, shock, friction or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames.
Purification Methods
Recrystallise MCPBA from CH2Cl2 [Traylor & Mikztal J Am Chem Soc 109 2770 1987]. Peracid of 99+% purity can be obtained by washing commercial 85% material with phosphate buffer pH 7.5 and drying the residue under reduced pressure. Alternatively the peracid can be freed from m-chlorobenzoic acid by dissolving 50g/L of *benzene and washing with an aqueous solution buffered at pH 7.4 (NaH2PO4/NaOH) (5 x 100mL). The organic layer is dried over MgSO4 and carefully evaporated under vacuum. Necessary care should be taken in case of EXPLOSION. The solid is recrystallised twice from CH2Cl2/Et2O and stored at 0o in a plastic container as glass catalyses the decomposition of the peracid. The acid is assayed iodometrically. [Schwartz & Blumbrgs J Org Chem 29 1976 1964, Bortolini et al. J Org Chem 52 5093 1987, McDonald et al. Org Synth Coll Vol VI 276 1988, Beilstein 9 IV 972.]
3-Chloroperoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| Otto Chemie Pvt. Ltd. | 58 |
| GLR Innovations | 58 |
| ANJI BIOSCIENCES | 58 |
| JSK Chemicals | 58 |
| Noble Molecular Research | 58 |
| Honest BioVet | 58 |
| Otto Chemie Pvt Ltd | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
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