PD158780
- CAS No.
- 171179-06-9
- Chemical Name:
- PD158780
- Synonyms
- PD 158780 solution;PD 158780; PD-158780;InSolution? PD 158780;PD 158780 - CAS 171179-06-9 - Calbiochem;InSolution PD 158780 - CAS 171179-06-9 - Calbiochem;N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference);PD158780,Inhibitor,Epidermal growth factor receptor,inhibit,HER1,EGFR,PD 158780,ErbB-1,PD-158780
- CBNumber:
- CB71074528
- Molecular Formula:
- C14H12BrN5
- Molecular Weight:
- 330.18
- MOL File:
- 171179-06-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 16:42:00
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2912.49.2600 | |||||||||
| NFPA 704 |
|
PD158780 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 513036 | InSolution PD 158780 - CAS 171179-06-9 - Calbiochem | 171179-06-9 | 500μG | ₹20250 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 513035 | PD 158780 - CAS 171179-06-9 - Calbiochem A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM). | 171179-06-9 | 500μG | ₹20250 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2567 | PD 158780 | 171179-06-9 | 10MG | ₹5600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2567 | PD 158780 | 171179-06-9 | 50MG | ₹16900 | 2022-05-26 | Buy |
PD158780 Chemical Properties,Uses,Production
Uses
PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models.
General Description
A potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 =49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.
Biological Activity
Potent inhibitor of ErbB receptor family tyrosine kinases (IC 50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G 1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
PD158780 Preparation Products And Raw materials
Raw materials
Preparation Products
PD158780 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7034 | 58 | Inquiry |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9991 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | China | 42057 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | China | 2989 | 60 | Inquiry |
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