Pimefylline
- CAS No.
- 10001-43-1
- Chemical Name:
- Pimefylline
- Synonyms
- ES-771;ES 771;Pimefylline;Pimephylline;Pimefyllinum;1,3-Dimethyl-7-[2-[(pyridin-3-yl)methylamino]ethyl]-1H-purine-2,6(3H,7H)-dione;3,7-Dihydro-1,3-dimethyl-7-[2-[(3-pyridylmethyl)amino]ethyl]-1H-purine-2,6-dione
- CBNumber:
- CB71118198
- Molecular Formula:
- C15H18N6O2
- Molecular Weight:
- 314.347
- MOL File:
- 10001-43-1.mol
- Modify Date:
- 2023/5/4 17:34:30
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): 1900 orally, 402 i.v. (Suter, Zutter, 1973) |
|---|
Pimefylline Chemical Properties,Uses,Production
Originator
Teonicon, Bracco, Italy ,1975
Manufacturing Process
77 g 7-(β-bromoethyl)-theophylline (C.A. 50, 12071f) and 57.8 g 3picolylamine in 750 ml toluene were refluxed 16 hours with vigorous agitation. The 3-picolylamine hydrobromide formed was filtered off, and the filtrate was evaporated in a vacuum to about one-third of its original volume. About 300 to 400 ml diisopropyl ether were added, and the solution was seeded with a few pure crystals of the desired product.
7-(β-3'-picolylaminoethyl)-theophylline crystallized over a period of a few hours. It was filtered off with suction, washed with a little diisopropyl ether, and dried. The yield of crude product was 69.3 g (82%), its MP 103° to 106°C. The MP was 111° to 112°C after recrystallization from isopropyl acetate. The compound was identified by microanalysis.
39.3 g 7-(β-3'-picolylaminoethyl)-theophylline were dissolved in 300 ml boiling isopropanol, and 15.4 g nicotinic acid were added to the solution in which the acid promptly dissolved. The nicotinate formed crystallized after a short time. It was filtered with suction and dried. The yield was 52.3 g (95.5%). The MP of 159° to 160°C was not significantly changed by recrystallization from ethanol.
Therapeutic Function
Coronary vasodilator
Pimefylline Preparation Products And Raw materials
Pimefylline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| 2A PharmaChem USA | (630) 737-0988 | United States | 6148 | 39 | Inquiry |
| Shanghai New Union Textra Import & Export Co., Ltd | +861-348-227-9455 | China | 2752 | 60 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Leancare Ltd. | +33 962096793 | United Kingdom | 6460 | 42 | Inquiry |
| Supplier | Advantage |
|---|---|
| 3B Scientific Corporation | 47 |
| 2A PharmaChem USA | 39 |
| Shanghai New Union Textra Import & Export Co., Ltd | 60 |
| Lanospharma Laboratories Co.,Ltd | 56 |
| Leancare Ltd. | 42 |